MicroRNAs: Novel Targets in Hepatic Ischemia-Reperfusion Injury.
MicroRNAs: Novel Targets in Hepatic Ischemia-Reperfusion Injury.
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DOI：
10.3390/biomedicines10040791
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发表时间：
2022-03-29
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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肝缺血再灌注损伤（IRI）是肝移植术后早期移植物功能障碍（EAD）的主要原因之一，可导致移植物排斥反应、移植物丢失或移植物寿命缩短。肝脏IRI似乎是不可避免的，在大多数肝脏采购和运输供体器官，导致一系列的生物学变化。IRI期间信号通路的激活导致基因和microRNA（miRNA）的上调和下调。miRNAs的长度约为21个核苷酸，其在基因调控中的作用已得到充分表征;除了作为许多疾病的生物标志物外，它们最近还被用于治疗方法。本文综述了在体外和体内动物模型中与肝脏IRI相关的miRNAs。在这些研究中，已经显示了对miRNA的操作用于抑制恶化的免疫应答、减少细胞凋亡、刺激组织修复和增强细胞恢复以减轻肝损伤。因此，利用肝脏特异性miRNA作为治疗剂具有很大的潜力，可以改善早期移植物功能障碍、肝损伤和患者预后。
Hepatic ischemia–reperfusion injury (IRI) is one of the main factors for early allograft dysfunction (EAD), which may lead to graft rejection, graft loss, or shortened graft life in liver transplantation. Hepatic IRI appears to be inevitable during the majority of liver procurement and transportation of donor organs, resulting in a cascade of biological changes. The activation of signaling pathways during IRI results in the up- and downregulation of genes and microRNAs (miRNAs). miRNAs are ~21 nucleotides in length and well-characterized for their role in gene regulations; they have recently been used for therapeutic approaches in addition to their role as biomarkers for many diseases. miRNAs that are associated with hepatic IRI in in vitro and in vivo animal models are comprehensively summarized in this review. In those studies, the manipulation of miRNAs has been shown for the inhibition of aggravated immune response, reduction of apoptosis, stimulation of tissue repair, and enhancement of cell recovery to attenuate liver damage. Therefore, the utilization of liver-specific miRNA holds great potential as a therapeutic agent to improve early allograft dysfunction, hepatic injury, and patient outcome.
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影响因子：
5.6
作者：
Feng, Min;Wang, Quanrongzi;Lu, Ling
通讯作者：
Lu, Ling
DOI：
10.1590/s0102-865020180080000008
发表时间：
2018-08-01
期刊：
Acta Cirúrgica Brasileira
影响因子：
--
作者：
Nakazato, Paula Carolina Grande;Victorino, João Paulo;Castro-e-Silva, Orlando
通讯作者：
Castro-e-Silva, Orlando
影响因子：
15.3
作者：
Cannistra, Marco;Ruggiero, Michele;Nardo, Bruno
通讯作者：
Nardo, Bruno
影响因子：
13.5
作者：
Anadol, Evrim;Schierwagen, Robert;Trebicka, Jonel
通讯作者：
Trebicka, Jonel
影响因子：
5.6
作者：
Ferrero G;Carpi S;Polini B;Pardini B;Nieri P;Impeduglia A;Grioni S;Tarallo S;Naccarati A
通讯作者：
Naccarati A