Interleukin-2 but not basic fibroblast growth factor is elevated in parkinsonian brain
Interleukin-2 but not basic fibroblast growth factor is elevated in parkinsonian brain
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帕金森病患者大脑中白介素 2 升高，但碱性成纤维细胞生长因子升高
DOI：
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发表时间：
2005
影响因子：
3.3
通讯作者：
Toshiharu Nagatsu
中科院分区：
文献类型：
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作者：
M. Mogi;M. Harada;T. Kondo;P. Riederer;Toshiharu Nagatsu
采用高灵敏度酶联免疫吸附法（ELISA）检测了正常人和帕金森病患者脑组织（尾状核、壳核和大脑皮质）中白细胞介素（IL）-2和碱性成纤维细胞生长因子（bFGF）的含量。脑组织中IL-2含量为pg/mg蛋白，且帕金森病患者尾状核和壳核中IL-2含量显著高于对照组。然而，大脑皮层中的IL-2水平在帕金森病患者和对照组之间没有显着差异。与IL-2相比，bFGF在脑中的水平高，并且在ng/mg蛋白的数量级，并且在尾状核和壳核中在帕金森病患者和对照组之间没有显著差异。虽然IL-2和bFGF都可能作为神经营养因子在多巴胺能神经元中发挥重要作用，但IL-2可能与帕金森病患者黑质纹状体多巴胺能区的代偿反应有关，而不是bFGF。
SummaryThe contents of interleukin (IL)-2 and basic fibroblast growth factor (bFGF) were measured in the brain (caudate nucleus, putamen, and cerebral cortex) from control and parkinsonian patients by highly sensitive enzyme-linked immunosorbent assay (ELISA). The concentrations of IL-2 in the brain were in the order of pg/mg protein, and the values were significantly higher in the caudate and putamen from parkinsonian patients than those from control patients. However, the levels of IL-2 in the cerebral cortex showed no significant difference between parkinsonian and control patients. In contrast to IL-2, the bFGF levels in the brain were high and in the order of ng/mg protein, and there was no significant difference in the caudate and putamen between parkinsonian and control patients. Although both IL-2 and bFGF may play important roles in dopaminergic neurons as neurotrophic factors, IL-2 but not bFGF may relate to the compensatory response in the nigrostriatal dopaminergic regions in parkinsonian brain during progress of neurodegeneration.
影响因子：
56.9
作者：
R. Morrison;H. Kornblum;F. Leslie;R. Bradshaw
通讯作者：
R. Morrison;H. Kornblum;F. Leslie;R. Bradshaw