Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering.
Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering.
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DOI：
10.1016/j.biomaterials.2018.05.012
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发表时间：
2019-04
期刊：
影响因子：
14
通讯作者：
Schmidt CE
中科院分区：
文献类型：
--
作者：
Mobini S;Song YH;McCrary MW;Schmidt CE
与用于研究脑、脊髓和周围神经组织再生的离体模型和芯片实验室设备相关的技术是神经组织工程和再生医学研究的重要工具。神经组织工程应用对离体系统、芯片实验室技术和疾病模型的需求正在出现，以克服传统体外系统和动物模型的不足和缺点。离体模型已经从传统的2D细胞培养模型发展到3D组织工程支架系统、生物反应器和最近的类器官试验床。除了离体模型系统，我们还讨论了专门用于神经组织工程应用的芯片实验室设备和技术。最后，我们回顾了目前的商业产品，模拟病变和正常的神经组织，并讨论了在这一领域的未来方向。
The technologies related to ex vivo models and lab-on-a-chip devices for studying the regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural tissue engineering and regenerative medicine research. The need for ex vivo systems, lab-on-a-chip technologies and disease models for neural tissue engineering applications are emerging to overcome the shortages and drawbacks of traditional in vitro systems and animal models. Ex vivo models have evolved from traditional 2D cell culture models to 3D tissue-engineered scaffold systems, bioreactors, and recently organoid test beds. In addition to ex vivo model systems, we discuss lab-on-a-chip devices and technologies specifically for neural tissue engineering applications. Finally, we review current commercial products that mimic diseased and normal neural tissues, and discuss the future directions in this field.
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影响因子：
23.9
作者：
Bershteyn M;Nowakowski TJ;Pollen AA;Di Lullo E;Nene A;Wynshaw-Boris A;Kriegstein AR
通讯作者：
Kriegstein AR
影响因子：
4.6
作者：
Bang S;Lee SR;Ko J;Son K;Tahk D;Ahn J;Im C;Jeon NL
通讯作者：
Jeon NL
影响因子：
3.4
作者：
Bonnici, Brenda;Kapfhammer, Josef P.
通讯作者：
Kapfhammer, Josef P.
影响因子：
--
作者：
Chafik, D;Bear, D;Gupta, RJ
通讯作者：
Gupta, RJ
影响因子：
3.2
作者：
Brown, Jacquelyn A.;Pensabene, Virginia;Wikswo, John P.
通讯作者：
Wikswo, John P.