Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda
Risk Factors and Seroprevalence of Hepatitis C among Patients Hospitalized at Mulago Hospital, Uganda
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乌干达穆拉戈医院住院患者丙型肝炎的危险因素和血清阳性率
DOI：
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发表时间：
2011
影响因子：
2.2
通讯作者：
A. Sofair
中科院分区：
文献类型：
--
作者：
J. O'Reilly;P. Ocama;Christopher Kenneth Opio;A. Alfred;Elijah Paintsil;E. Seremba;A. Sofair
丙型肝炎病毒（HCV）及其相关后遗症在非洲的出现令人严重关切。人类免疫缺陷病毒（HIV）阳性患者由于相似的风险因素和传播方式，感染HCV的风险增加。我们调查了乌干达一家学术医院Mulago医院住院的HIV阳性和HIV阴性患者的丙型肝炎血清阳性率。首先对血液样本进行HCV抗体检测，并用HCV RNA PCR确认阳性检测。我们招募了500名患者，一半是HIV阳性，一半是HIV阴性。总体而言，13/500例患者（2.6%）HCV抗体检测呈阳性。HIV阳性和阴性患者的HCV抗体检测结果无差异。在所有检查的风险因素中，只有年龄大于50岁与HCV感染相关。艾滋病毒和丙型肝炎病毒同时传播的传统危险因素，如静脉注射毒品，在乌干达极为罕见。13例HCV抗体阳性患者中，仅有3例经HCVRNA检测确诊。这一结果与最近的研究一致，指出使用非洲血清时HCV抗体检测性能不佳。这些测试应在实施前在当地人群中进行验证。
The emergence of hepatitis C virus (HCV) and its associated sequelae in Africa is a cause for significant concern. Human immunodeficiency virus (HIV) positive patients are at an increased risk of contracting HCV infection due to similar risk factors and modes of transmission. We investigated the seroprevalence of hepatitis C in hospitalized HIV-positive and HIV-negative patients in Mulago Hospital, an academic hospital in Uganda. Blood samples were first tested for HCV antibodies, and positive tests were confirmed with HCV RNA PCR. We enrolled five hundred patients, half HIV-positive and half HIV negative. Overall, 13/500 patients (2.6%) tested positive for HCV antibodies. There was no difference in HCV antibody detection among HIV-positive and HIV-negative patients. Out of all risk factors examined, only an age greater than 50 years was associated with HCV infection. Traditional risk factors for concurrent HIV and HCV transmission, such as intravenous drug use, were exceedingly rare in Uganda. Only 3 of 13 patients with detectable HCV antibodies were confirmed by HCV RNA detection. This result concurs with recent studies noting poor performance of HCV antibody testing when using African sera. These tests should be validated in the local population before implementation.
影响因子：
120.7
作者：
Sulkowski, MS;Moore, RD;Thomas, DL
通讯作者：
Thomas, DL
HIV感染后CD4 T细胞依赖性丙型肝炎病毒特异性体液免疫反应的减少。
DOI：
10.1086/511826
发表时间：
2007
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Netski,DaleM;Mosbruger,Tim;Astemborski,Jacquie;Mehta,ShrutiH;Thomas,DavidL;Cox,AndreaL
通讯作者：
Cox,AndreaL
DOI：
10.1056/nejmc071236
发表时间：
2007
期刊：
The New England journal of medicine
影响因子：
--
作者：
S. Leiner
通讯作者：
S. Leiner