Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals.
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals.
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DOI：
10.1126/sciadv.aar6849
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发表时间：
2018-05
期刊：
影响因子：
13.6
通讯作者：
Monroig Ó
中科院分区：
文献类型：
--
作者：
Kabeya N;Fonseca MM;Ferrier DEK;Navarro JC;Bay LK;Francis DS;Tocher DR;Castro LFC;Monroig Ó
多种无脊椎动物具有能够从头生物合成必需ω-3脂肪酸的酶。海洋生态系统负责几乎所有的欧米茄-3（ω3）长链多不饱和脂肪酸（PUFA）的生产，这是脊椎动物的必需营养素。目前的共识是，海洋微生物解释了这种生产，因为它们拥有关键酶，包括甲基末端（或“ωx”）去饱和酶。在少数无脊椎动物中也描述了ωx去饱和酶，但尚未系统地探索其精确分布。本研究从刺胞动物门、轮虫门、软体动物门、环节动物门和节肢动物门的80个物种中鉴定了121个ωx去饱和酶序列。水平基因转移促成了这种迄今为止未知的广泛分布。动物ωx去饱和酶的功能特性提供了证据，表明多种无脊椎动物具有从头产生ω3 PUFA并进一步生物合成ω3长链PUFA的能力。这一发现代表了我们对全球食物网中ω3长链PUFA产生的理解的根本性修订，揭示了许多广泛而丰富的无脊椎动物具有内源性能力，可以做出超出海洋微生物的重大贡献。
Multiple invertebrates possess enzymes enabling de novo biosynthesis of essential omega-3 fatty acids. Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or “ωx”) desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes.
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影响因子：
3.7
作者：
Kabeya N;Sanz-Jorquera A;Carboni S;Davie A;Oboh A;Monroig O
通讯作者：
Monroig O
DOI：
10.1073/pnas.1706865114
发表时间：
2017-07-18
影响因子：
11.1
作者：
Bryon, Astrid;Kurlovs, Andre H.;Van Leeuwen, Thomas
通讯作者：
Van Leeuwen, Thomas
DOI：
10.1098/rspb.2013.2450
发表时间：
2014-02-22
影响因子：
4.7
作者：
Boto, Luis
通讯作者：
Boto, Luis
影响因子：
48
作者：
Remmert, Michael;Biegert, Andreas;Soeding, Johannes
通讯作者：
Soeding, Johannes
影响因子：
12.3
作者：
Crisp A;Boschetti C;Perry M;Tunnacliffe A;Micklem G
通讯作者：
Micklem G