Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.
Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.
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DOI：
10.1371/journal.pone.0006523
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发表时间：
2009-08-05
期刊：
影响因子：
3.7
通讯作者：
Helzlsouer K
中科院分区：
文献类型：
--
作者：
Chae YK;Huang HY;Strickland P;Hoffman SC;Helzlsouer K
雌激素可能参与前列腺癌的发展。在马里兰州华盛顿县进行的一项巢式病例对照研究中，检测了雌激素受体α（ESR 1）和β（ESR 2）基因多态性与前列腺癌风险之间的关系。根据年龄、性别、种族和献血日期，将前列腺癌发病病例（n = 269）与一名或两名对照（n =440）进行匹配。 雌激素受体基因型或饮食摄入量与前列腺癌的发展之间的关系在条件Logistic回归模型中进行了研究。本研究的结果表明，ESR 1基因的6个单碱基对多态性（SNPs）（rs 1801132，rs 2077647，rs746432，rs 2273206，rs 851982，rs 2228480）和ESR 2的4个SNP（rs 4986938，rs 928554，rs 8018687，rs number not available for ESR 2 5696 bp 3′ of STP A>G）与前列腺癌风险无显著相关性，无论是等位基因频率还是基因型频率。然而，在前列腺癌风险与STP G>A（rs 4986938）的ESR 2 38 bp 3′基因型之间的关系中观察到与BMI的交互关联（p = 0.031）。 观察到植物雌激素的摄入水平和ESR 1 Ex 1 - 192 G>C（rs746432）基因型之间以及植物雌激素的摄入水平和ESR 1 Ex 8 + 229 G>A（rs 2228480）基因型之间与前列腺癌风险之间的相互作用（分别为p= 0.0009和p =0.044）。 总之，ESR 1和ESR 2的选定遗传多态性总体上与前列腺癌风险无关。然而，BMI和植物雌激素摄入量的风险变化也有牵连。
Estrogen may be involved in the development of prostate cancer. The association between genetic polymorphisms of estrogen receptors α (ESR1) and β (ESR2) and prostate cancer risk was examined in a nested case-control study in Washington County, Maryland. Incident prostate cancer cases (n = 269) were matched to one or two controls (n = 440) by age, sex, race, and date of blood donation. Associations between estrogen receptor genotypes or dietary intake and the development of prostate cancer were examined in conditional logistic regression models. Results from this study showed that six single base-pair polymorphisms (SNPs) of ESR1 (rs1801132, rs2077647, rs746432, rs2273206, rs851982, rs2228480) and four SNPs of ESR2 (rs4986938, rs928554, rs8018687, rs number not available for ESR2 5696 bp 3′ of STP A>G) were not significantly associated with prostate cancer risk, either by allelic or genotypic frequencies. However, an interactive association with BMI was observed in the relationship between prostate cancer risk and genotypes of ESR2 38 bp 3′ of STP G>A (rs4986938) (p = 0.031). An interaction between intake level of phytoestrogen and genotypes of ESR1 Ex1-192G>C (rs746432) and between intake level of phytoestrogen and genotypes of ESR1 Ex8+229G>A (rs2228480) and risk of prostate cancer was observed (p = 0.0009 and p = 0.044, respectively). In conclusion, selected genetic polymorphisms of ESR1 and ESR2, overall, were not associated with prostate cancer risk. However, a variation in risk by BMI and phytoestrogen intake was implicated.
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影响因子：
2.1
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Lai, JS;Brown, LG;Corey, E
通讯作者：
Corey, E
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3.5
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作者：
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