Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration.

Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration.
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DOI:
10.1186/s41232-022-00234-6
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发表时间:
2022-11-16
影响因子:
8.1
通讯作者:
--
中科院分区:
医学3区
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--
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骨骼肌在受伤时具有非凡的自我再生能力。骨骼肌干细胞,称为卫星细胞,通过三个主要步骤在肌肉再生中发挥核心作用:激活,增殖和分化。这些步骤受到多种类型细胞的影响,例如免疫细胞、纤维脂肪生成祖细胞和血管内皮细胞。单细胞测序技术的广泛使用使得能够鉴定与肌肉再生及其调控机制相关的新细胞亚群。本文综述了控制和促进肌肉再生的细胞群落的动态,特别关注骨骼肌干细胞。
Skeletal muscles have an extraordinary capacity to regenerate themselves when injured. Skeletal muscle stem cells, called satellite cells, play a central role in muscle regeneration via three major steps: activation, proliferation, and differentiation. These steps are affected by multiple types of cells, such as immune cells, fibro-adipogenic progenitor cells, and vascular endothelial cells. The widespread use of single-cell sequencing technologies has enabled the identification of novel cell subpopulations associated with muscle regeneration and their regulatory mechanisms. This review summarizes the dynamism of the cellular community that controls and promotes muscle regeneration, with a particular focus on skeletal muscle stem cells.
骨骼肌再生中的干细胞激活
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