SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease.
SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease.
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DOI：
10.1007/s00259-016-3480-8
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发表时间：
2016-12
影响因子：
9.1
通讯作者：
Mottaghy, Felix M.
中科院分区：
文献类型：
--
作者：
Hendrikx, Geert;Voo, Stefan;Bauwens, Matthias;Post, Mark J.;Mottaghy, Felix M.
新生血管的形成程度决定了冠状动脉疾病和其他闭塞性心血管疾病的临床预后。因此对新生血管的监测是非常重要的。这篇综述文章将详细讨论旨在验证新的核血管生成和动脉生成示踪剂的临床前研究。此外，我们将简要介绍在设计动脉生成放射性示踪剂时应考虑的可能障碍。结构化的医学检索是本综述的基础，它概述了在临床前模型中评估的不同放射性药物。新生血管是一个集合术语，用来表示不同的过程，如血管生成和动脉生成。然而，虽然假设通过核成像的敏感检测将有助于临床前模型成功的治疗干预转化为床边，但我们仍然缺乏用于新生血管成像的特异性示踪剂。迄今为止，大多数核成像研究都集中在血管生成上，而核动脉生成成像在很大程度上被忽视了。虽然血管生成是最容易理解的过程，但动脉生成成像的理论目标并不缺乏。
The extent of neovascularization determines the clinical outcome of coronary artery disease and other occlusive cardiovascular disorders. Monitoring of neovascularization is therefore highly important. This review article will elaborately discuss preclinical studies aimed at validating new nuclear angiogenesis and arteriogenesis tracers. Additionally, we will briefly address possible obstacles that should be considered when designing an arteriogenesis radiotracer. A structured medline search was the base of this review, which gives an overview on different radiopharmaceuticals that have been evaluated in preclinical models. Neovascularization is a collective term used to indicate different processes such as angiogenesis and arteriogenesis. However, while it is assumed that sensitive detection through nuclear imaging will facilitate translation of successful therapeutic interventions in preclinical models to the bedside, we still lack specific tracers for neovascularization imaging. Most nuclear imaging research to date has focused on angiogenesis, leaving nuclear arteriogenesis imaging largely overlooked. Although angiogenesis is the process which is best understood, there is no scarcity in theoretical targets for arteriogenesis imaging.
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分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
DOI：
10.1161/01.atv.0000245807.65714.0b
发表时间：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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