Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.
Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.
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DOI：
10.1001/archgenpsychiatry.2010.14
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发表时间：
2010-04
影响因子：
--
通讯作者：
Caspi, Avshalom
中科院分区：
文献类型：
--
作者：
Polanczyk, Guilherme;Moffitt, Terrie E.;Arseneault, Louise;Cannon, Mary;Ambler, Antony;Keefe, Richard S. E.;Houts, Renate;Odgers, Candice L.;Caspi, Avshalom
据报道，儿童精神病症状在一般人群中很常见，可能预示着导致精神分裂症的神经发育过程。然而，尚不清楚这些症状是否与成人精神分裂症的同样广泛的危险因素有关。通过检验儿童自述精神病症状是否具有成人精神分裂症的危险因素和临床特征，来检验儿童自述精神病症状的构念效度。英国一项具有全国代表性的出生队列的前瞻性纵向队列研究。从5岁开始随访的12岁儿童2232例（保留率96%）。儿童自我报告的幻觉和妄想。儿童精神病症状具有家族性和遗传性，并与社会风险因素（如城市化）有关；5岁时认知障碍；家庭养育风险因素（例如，母亲表达的情绪）；5岁时的行为、情绪和教育问题；以及伴随疾病，包括自残。研究结果对儿童自我报告精神病症状的构念效度提供了一个全面的认识。对于研究人员来说，这些发现表明，有精神病症状的儿童可以被招募进行神经科学研究，以确定精神分裂症的发病机制。对于临床医生来说，研究结果表明，儿童时期的精神病症状通常是发育过程受损的标志，应该积极评估。
It has been reported that childhood psychotic symptoms are common in the general population and may signal neurodevelopmental processes that lead to schizophrenia. However, it is not clear whether these symptoms are associated with the same extensive risk factors established for adult schizophrenia. To examine the construct validity of children’s self-reported psychotic symptoms by testing whether these symptoms share the risk factors and clinical features of adult schizophrenia. Prospective, longitudinal cohort study of a nationally representative birth cohort in Great Britain. A total of 2232 twelve-year-old children followed up since age 5 years (retention, 96%). Children’s self-reported hallucinations and delusions. Children’s psychotic symptoms are familial and heritable and are associated with social risk factors (eg, urbanicity); cognitive impairments at age 5; home-rearing risk factors (eg, maternal expressed emotion); behavioral, emotional, and educational problems at age 5; and comorbid conditions, including self-harm. The results provide a comprehensive picture of the construct validity of children’s self-reported psychotic symptoms. For researchers, the findings indicate that children who have psychotic symptoms can be recruited for neuroscience research to determine the pathogenesis of schizophrenia. For clinicians, the findings indicate that psychotic symptoms in childhood are often a marker of an impaired developmental process and should be actively assessed.
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DOI：
10.1111/j.1469-7610.1995.tb01366.x
发表时间：
1995-10-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
GJONE, H;NOVIK, TS
通讯作者：
NOVIK, TS
影响因子：
6.9
作者：
Dhossche, D;Ferdinand, R;Verhulst, F
通讯作者：
Verhulst, F
影响因子：
6.6
作者：
Dutta, Rina;Greene, Talya;Murray, Robin M.
通讯作者：
Murray, Robin M.
影响因子：
10.5
作者：
Hollis, C
通讯作者：
Hollis, C
影响因子：
4
作者：
Caspi, A;Moffitt, TE;Polo-Tomas, M
通讯作者：
Polo-Tomas, M