A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro.
A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro.
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DOI：
10.1016/j.cellimm.2013.04.014
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发表时间：
2013-04
影响因子：
4.3
通讯作者：
Kurt RA
中科院分区：
文献类型：
--
作者：
Chalmers SA;Eidelman AS;Ewer JC;Ricca JM;Serrano A;Tucker KC;Vail CM;Kurt RA
之前我们报道过 Myd88 有助于肿瘤进展。为了开始破译可能诱导 Myd88 依赖性信号传导的因素，我们重点关注可充当损伤相关分子模式分子 (DAMP) 的蛋白质，因为据报道 DAMP 由肿瘤分泌，并且某些 DAMP 通过 Toll 样受体介导作用。乳腺癌 DAMP 表达筛查显示，HMGB1 和 HSP60 相对于正常乳腺上皮显着升高，靶向这些 DAMP 或这些 DAMP 的受体会影响肿瘤细胞的生长。此外，使用Myd88抑制肽的分析表明，HMGB1以Myd88依赖性方式介导其作用，抑制Myd88功能会降低HMGB1和HSP60基因表达。总的来说，这些数据表明 HMGB1 和 HSP60 有助于乳腺癌细胞的生长，HMGB1 至少部分通过 Myd88 依赖性信号传导实现这一点，并且这些 DAMP 以 Myd88 依赖性方式表达。
Previously we reported that Myd88 contributed to tumor progression. To begin to decipher what may be inducing Myd88 dependent signaling we focused on proteins that could function as damage associated molecular pattern molecules (DAMPs) since DAMPs have been reported to be secreted by tumors, and certain DAMPs mediate effects through toll-like receptors. A screen of mammary carcinoma for DAMP expression showed HMGB1 and HSP60 were significantly elevated relative to normal mammary epithelium, and targeting these DAMPs, or receptors for these DAMPs influenced growth of tumor cells. Moreover, analysis using a Myd88 inhibitory peptide suggested that HMGB1 mediated its effects in a Myd88 dependent manner, and inhibiting Myd88 function decreased HMGB1 and HSP60 gene expression. Collectively, these data suggest that HMGB1 and HSP60 contribute to growth of mammary carcinoma cells, HMGB1 accomplishes this, at least in part, through Myd88 dependent signaling, and these DAMPs are expressed in a Myd88 dependent manner.
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影响因子：
4.3
作者：
Egunsola, Adetutu T.;Zawislak, Carolyn L.;Akuffo, Afua A.;Chalmers, Samantha A.;Ewer, Jason C.;Vail, Caroline M.;Lombardo, Jeffrey C.;Perez, Dana N.;Kurt, Robert A.
通讯作者：
Kurt, Robert A.
影响因子：
4.7
作者：
Tsai, Ya-Ping;Yang, Muh-Hwa;Wu, Kou-Juey
通讯作者：
Wu, Kou-Juey
影响因子：
5.5
作者：
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通讯作者：
Abraham, E
影响因子：
4.3
作者：
De Sousa, Chiquita Palha;Blum, Christopher M.;Kurt, Robert A.
通讯作者：
Kurt, Robert A.
高迁移率族盒 1 蛋白通过 CD11c（低）CD45RB（高）树突状细胞分化抑制 T 细胞介导的免疫。
影响因子：
3.8
作者：
Liu, Qing-yang;Yao, Yong-ming;Sheng, Zhi-yong
通讯作者：
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