Antioxidant activity of Ganoderma lucidum in acute ethanol‐induced heart toxicity
Antioxidant activity of Ganoderma lucidum in acute ethanol‐induced heart toxicity
复制标题
灵芝在急性乙醇引起的心脏毒性中的抗氧化活性
作者：
Kar;Hung;P. Chan;Li;Chi‐Feng Liu
灵芝热水提取物对心脏毒性具有抗氧化作用。还对作用机制、体内脂质过氧化水平和超氧化物清除活性进行了研究。将小鼠分成六组，每组十只动物。灵芝，剂量为10、25和50 mg[sol ]kg（p.o.）被管理。用紫外分光光度计用细胞色素C还原法测定超氧阴离子。本研究结果表明，灵芝对小鼠心脏匀浆中的脂质过氧化和超氧化物清除活性表现出剂量依赖性的抗氧化作用。此外，这一结果表明，与灵芝处理的心脏匀浆相比，乙醇诱导的心脏损伤显示出更高的丙二醛水平。因此，灵芝的抗氧化活性可能有助于心脏保护作用，并因此可能保护心脏免受超氧化物损伤。版权所有© 2004年约翰威利父子有限公司。
The hot water extract of the mushroom Ganoderma lucidum was shown to have antioxidative effect against heart toxicity. Investigations into the mechanisms of action, level of lipid peroxidation level in vivo, and superoxide scavenging activity were also conducted. The mice were divided into six groups with ten animals in each group. Ganoderma lucidum, at doses of 10, 25 and 50 mg[sol ]kg (p.o.) was administered. Superoxide anions were assayed by UV spectrophotometer using the cytochrome C reduction method. The results of this study showed that Ganoderma lucidum exhibited a dose‐dependent antioxidative effect on lipid peroxidation and superoxide scavenging activity in mouse heart homogenate. Additionally, this result indicated that heart damage induced by ethanol shows a higher malonic dialdehyde level compared with heart homogenate treated with Ganoderma lucidum. It is concluded that the antioxidative activity may therefore contribute to the cardioprotective effect of Ganoderma lucidum, and may therefore protect the heart from superoxide induced damage. Copyright © 2004 John Wiley & Sons, Ltd.
DOI：
10.1073/pnas.84.24.9223
发表时间：
1987-12
影响因子：
11.1
作者：
L. A. Reinke;E. Lai;C. M. Dubose;P. McCay
通讯作者：
L. A. Reinke;E. Lai;C. M. Dubose;P. McCay