Heterogeneity in the initiation, development and function of type 2 immunity.
Heterogeneity in the initiation, development and function of type 2 immunity.
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DOI：
10.1038/s41577-020-0301-x
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发表时间：
2020-10
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影响因子：
--
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2型免疫反应在不同的组织环境中在不同的条件下发挥作用，对于预防蠕虫感染和维持组织内环境稳定至关重要。在这里，我们探索不同层次的异质性是如何影响2型免疫的。不同的侮辱，如过敏原或感染，可以通过不同的机制诱导2型免疫反应，这可能会产生不同的后果，从急性或慢性炎症到免疫调节和组织修复的缺陷。技术进步为2型免疫细胞不同发育谱系的分子异质性提供了新的见解。遗传和环境的异质性也导致感染期间2型免疫反应的大小和质量不同，这是病理和疾病解决之间平衡的重要决定因素。因此，了解个体之间和不同组织之间2型免疫反应异质性的潜在机制对于治疗2型免疫是其中重要组成部分的疾病至关重要。
Type 2 immune responses operate under varying conditions in distinct tissue environments and are crucial for protection against helminth infections and for the maintenance of tissue homeostasis. Here we explore how different layers of heterogeneity influence type 2 immunity. Distinct insults, such as allergens or infections, can induce type 2 immune responses through diverse mechanisms, and this can have heterogeneous consequences, ranging from acute or chronic inflammation to deficits in immune regulation and tissue repair. Technological advances have provided new insights into the molecular heterogeneity of different developmental lineages of type 2 immune cells. Genetic and environmental heterogeneity also contributes to the varying magnitude and quality of the type 2 immune response during infection, which is an important determinant of the balance between pathology and disease resolution. Hence, understanding the mechanisms underlying the heterogeneity of type 2 immune responses between individuals and between different tissues will be crucial for treating diseases in which type 2 immunity is an important component.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allakhverdi Z;Comeau MR;Jessup HK;Yoon BR;Brewer A;Chartier S;Paquette N;Ziegler SF;Sarfati M;Delespesse G
通讯作者：
Delespesse G
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
64.8
作者：
Cardoso V;Chesné J;Ribeiro H;García-Cassani B;Carvalho T;Bouchery T;Shah K;Barbosa-Morais NL;Harris N;Veiga-Fernandes H
通讯作者：
Veiga-Fernandes H
影响因子：
16.6
作者：
Belle, Nicole Maloney;Ji, Yingbiao;Herbert, De'Broski R.
通讯作者：
Herbert, De'Broski R.