A Genome-Wide Association Study Identifies the Association between the 12q24 Locus and Black Tea Consumption in Japanese Populations.
A Genome-Wide Association Study Identifies the Association between the 12q24 Locus and Black Tea Consumption in Japanese Populations.
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DOI：
10.3390/nu12103182
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发表时间：
2020-10-18
期刊：
影响因子：
5.9
通讯作者：
Kato H
中科院分区：
文献类型：
--
作者：
Furukawa K;Igarashi M;Jia H;Nogawa S;Kawafune K;Hachiya T;Takahashi S;Saito K;Kato H
一些全基因组关联研究（GWAS）报告了遗传变异与习惯性食物和饮料消费之间的关联;然而，没有关于红茶消费的关联数据。本研究旨在确定与12，258名日本参与者的红茶消费相关的遗传变异。红茶消费量的数据通过自填式问卷收集，基因型数据从单核苷酸多态性阵列获得。在GWAS的发现中，有两个位点具有提示意义（p < 1.0 × 10−6）。12 q24位点的三个遗传变异（rs 2074356，rs 144504271和rs 12231737）也与复制阶段（p < 0.05）和荟萃分析期间（p < 5.0 × 10−8）的红茶消费量显著相关。rs 2074356与红茶消费的关联通过饮酒频率的额外调整而略微减弱。总之，12 q24基因座的遗传变异与日本人群的红茶消费量相关，这种关联至少部分由饮酒频率介导。
Several genome-wide association studies (GWASs) have reported the association between genetic variants and the habitual consumption of foods and drinks; however, no association data are available regarding the consumption of black tea. The present study aimed to identify genetic variants associated with black tea consumption in 12,258 Japanese participants. Data on black tea consumption were collected by a self-administered questionnaire, and genotype data were obtained from a single nucleotide polymorphism array. In the discovery GWAS, two loci met suggestive significance (p < 1.0 × 10−6). Three genetic variants (rs2074356, rs144504271, and rs12231737) at 12q24 locus were also significantly associated with black tea consumption in the replication stage (p < 0.05) and during the meta-analysis (p < 5.0 × 10−8). The association of rs2074356 with black tea consumption was slightly attenuated by the additional adjustment for alcohol drinking frequency. In conclusion, genetic variants at the 12q24 locus were associated with black tea consumption in Japanese populations, and the association is at least partly mediated by alcohol drinking frequency.
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影响因子：
5
作者：
Fang, C-M;Roy, S.;Nielsen, E.;Paul, M.;Maul, R.;Paun, A.;Koentgen, F.;Raval, F. M.;Szomolanyi-Tsuda, E.;Pitha, P. M.
通讯作者：
Pitha, P. M.
日本人群中全基因组协会的研究确定了习惯性咖啡消费的12q24基因座：J-MICC研究。
影响因子：
4.6
作者：
Nakagawa-Senda H;Hachiya T;Shimizu A;Hosono S;Oze I;Watanabe M;Matsuo K;Ito H;Hara M;Nishida Y;Endoh K;Kuriki K;Katsuura-Kamano S;Arisawa K;Nindita Y;Ibusuki R;Suzuki S;Hosono A;Mikami H;Nakamura Y;Takashima N;Nakamura Y;Kuriyama N;Ozaki E;Furusyo N;Ikezaki H;Nakatochi M;Sasakabe T;Kawai S;Okada R;Hishida A;Naito M;Wakai K;Momozawa Y;Kubo M;Tanaka H
通讯作者：
Tanaka H
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
30.8
作者：
Loh, Po-Ru;Danecek, Petr;Palamara, Pier Francesco;Fuchsberger, Christian;Reshef, Yakir A.;Finucane, Hilary K.;Schoenherr, Sebastian;Forer, Lukas;McCarthy, Shane;Abecasis, Goncalo R.;Durbin, Richard;Price, Alkes L.
通讯作者：
Price, Alkes L.
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ