Impact of 18F-FDG PET/MR based tumor delineation in radiotherapy planning for cholangiocarcinoma.
Impact of 18F-FDG PET/MR based tumor delineation in radiotherapy planning for cholangiocarcinoma.
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DOI：
10.1007/s00261-021-03053-4
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Heidari P
中科院分区：
文献类型：
--
作者：
Delaby G;Ataeinia B;Wo J;Catalano OA;Heidari P
放射治疗（RT）是治疗不能切除的胆管癌（CC）的有效方法。准确的肿瘤体积描绘对于实现高的局部控制率同时最小化治疗相关毒性至关重要。本研究比较了18F-FDG PET/MR与MR和CT在RT计划靶区勾画方面的差异。我们回顾性地纳入了22例新诊断的不可切除的原发性CC患者，这些患者接受了18F-FDG PET/MR进行初始分期。在CT图像、MR图像和PET/MR融合图像上描绘原发性肿块（GTVM）和淋巴结（GTVLN）的大体肿瘤体积（GTV），并在不同模式之间进行比较。计算骰子相似系数（DSC），以评估不同模式之间的空间覆盖。 （中位数：94 ml，范围16-655 ml）显著大于（69 ml，11-635 ml）（p = 0.0001）和（96 ml，4-564 ml）（p = 0.035）。与之间无显著差异（p = 0.078）。肝内和肝外肿瘤的亚组分析显示，中位数显著高于两组（分别为117.5 ml，22-655 ml vs. 102.5 ml，22-635 ml，p = 0.004和37 ml，16-303 ml vs. 34 ml，11-207 ml，p = 0.042）。（8.5 ml，1-27 ml）显著高于（5 ml，4-16 ml）（p = 0.026）。GTVPET/MR与GTVMR具有最高的相似性，即，DSCPET/MR-MR（0.82，0.25-1.00），相比之下，DSC PET/MR-CT为0.58（0.22-0.87），DSCMR-CT为0.58（0.03-0.83）。与CT或MR相比，基于18F-FDG PET/MR的CC描绘产生更大的GTV，并检测到更多的阳性淋巴结，通过降低地理遗漏的风险可能改善RT计划。
Radiation therapy (RT) is an effective treatment for unresectable cholangiocarcinoma (CC). Accurate tumor volume delineation is critical in achieving high rates of local control while minimizing treatment-related toxicity. This study compares 18F-FDG PET/MR to MR and CT for target volume delineation for RT planning. We retrospectively included 22 patients with newly diagnosed unresectable primary CC who underwent 18F-FDG PET/MR for initial staging. Gross tumor volume (GTV) of the primary mass (GTVM) and lymph nodes (GTVLN) were contoured on CT images, MR images, and PET/MR fused images and compared among modalities. The dice similarity coefficient (DSC) was calculated to assess spatial coverage between different modalities. (median: 94 ml, range 16–655 ml) was significantly greater than (69 ml, 11–635 ml) (p = 0.0001) and (96 ml, 4–564 ml) (p = 0.035). There was no significant difference between and (p = 0.078). Subgroup analysis of intrahepatic and extrahepatic tumors showed that the median was significantly greater than in both groups (117.5 ml, 22–655 ml vs. 102.5 ml, 22–635 ml, p = 0.004 and 37 ml, 16–303 ml vs. 34 ml, 11–207 ml, p = 0.042, respectively). The (8.5 ml, 1–27 ml) was significantly higher than (5 ml, 4–16 ml) (p = 0.026). GTVPET/MR had the highest similarity to the GTVMR, i.e., DSCPET/MR-MR (0.82, 0.25–1.00), compared to DSC PET/MR-CT of 0.58 (0.22–0.87) and DSCMR-CT of 0.58 (0.03–0.83). 18F-FDG PET/MR-based CC delineation yields greater GTVs and detected a higher number of positive lymph nodes compared to CT or MR, potentially improving RT planning by reducing the risk of geographic misses.
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影响因子：
19.7
作者：
Melsaether AN;Raad RA;Pujara AC;Ponzo FD;Pysarenko KM;Jhaveri K;Babb JS;Sigmund EE;Kim SG;Moy LA
通讯作者：
Moy LA
影响因子：
1.5
作者：
Ma, Jie-Tao;Han, Cheng-Bo;Guo, Qi-Yong
通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
Liu, Nai-Jen
影响因子：
2.3
作者：
Guro, Hanisah;Kim, Jin Won;Han, Ho-Seong
通讯作者：
Han, Ho-Seong
影响因子：
3.7
作者：
Choi, Sae-Byeol;Kim, Kyung-Sik;Chung, Jae-Bock
通讯作者：
Chung, Jae-Bock