Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides.
Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides.
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DOI：
10.1039/d1fd00061f
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发表时间：
2021-12-24
影响因子：
3.4
通讯作者：
DeGrado WF
中科院分区：
文献类型：
--
作者：
Kratochvil HT;Newberry RW;Mensa B;Mravic M;DeGrado WF
Membrane–peptide interactions play critical roles in many cellular and organismic functions, including protection from infection, remodeling of membranes, signaling, and ion transport. Peptides interact with membranes in a variety of ways: some associate with membrane surfaces in either intrinsically disordered conformations or well-defined secondary structures. Peptides with sufficient hydrophobicity can also insert vertically as transmembrane monomers, and many associate further into membrane-spanning helical bundles. Indeed, some peptides progress through each of these stages in the process of forming oligomeric bundles. In each case, the structure of the peptide and the membrane represent a delicate balance between peptide–membrane and peptide–peptide interactions. We will review this literature from the perspective of several biologically important systems, including antimicrobial peptides and their mimics, α-synuclein, receptor tyrosine kinases, and ion channels. We also discuss the use of de novo design to construct models to test our understanding of the underlying principles and to provide useful leads for pharmaceutical intervention of diseases.
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影响因子：
5.6
作者：
Barrera, Francisco N.;Weerakkody, Dhammika;Engelman, Donald M.
通讯作者：
Engelman, Donald M.
影响因子：
2.9
作者：
Arvidsson, PI;Ryder, NS;Seebach, D
通讯作者：
Seebach, D
DOI：
10.1073/pnas.80.21.6475
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ANDREU, D;MERRIFIELD, RB;BOMAN, HG
通讯作者：
BOMAN, HG
影响因子：
3.7
作者：
Barlow PG;Svoboda P;Mackellar A;Nash AA;York IA;Pohl J;Davidson DJ;Donis RO
通讯作者：
Donis RO
影响因子：
4
作者：
Andreev OA;Engelman DM;Reshetnyak YK
通讯作者：
Reshetnyak YK