Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder.
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder.
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DOI：
10.1016/j.pscychresns.2011.08.006
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发表时间：
2011-12-30
影响因子：
2.3
通讯作者：
Hirsch, Joy
中科院分区：
文献类型：
--
作者：
Schneier, Franklin R.;Pomplun, Marc;Sy, Melissa;Hirsch, Joy
Generalized social anxiety disorder (GSAD) is characterized by excessive fears of scrutiny and negative evaluation, but neural circuitry related to scrutiny in GSAD has been little-studied. In this study, 16 unmedicated adults with GSAD and 16 matched healthy comparison (HC) participants underwent functional MRI to assess neural response to viewed images of faces simulating movement into eye contact versus away from eye contact. GSAD patients were then treated for eight weeks with paroxetine and 15 patients were re-imaged. At baseline, GSAD patients had elevated neural response to eye contact in parahippocampal cortex, inferior parietal lobule, supramarginal gyrus, posterior cingulate and middle occipital cortex. During paroxetine treatment, symptomatic improvement was associated with decreased neural response to eye contact in regions including inferior and middle frontal gyri, anterior cingulate, posterior cingulate, precuneus and inferior parietal lobule. Magnitude of GSAD symptom reduction with paroxetine treatment, and GSAD diagnosis in comparison to HCs at baseline, were both associated with neural processing of eye contact in distributed networks that included regions involved in self-referential processing. These findings demonstrate that eye contact in GSAD engages neurocircuitry consistent with the heightened self-conscious emotional states known to characterize GSAD patients during scrutiny.
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