The Minnesota Center for Twin and Family Research genome-wide association study.

The Minnesota Center for Twin and Family Research genome-wide association study.
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DOI:
10.1017/thg.2012.62
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发表时间:
2012-12
影响因子:
0.9
通讯作者:
McGue, Matt
McGue, Matt
中科院分区:
医学4区
文献类型:
--
作者:
Miller, Michael B.;Basu, Saonli;Cunningham, Julie;Eskin, Eleazar;Malone, Steven M.;Oetting, William S.;Schork, Nicholas;Sul, Jae Hoon;Iacono, William G.;McGue, Matt

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作为基因、环境和发展倡议(GEDI)的一部分,明尼苏达州双胞胎和家庭研究中心(MCTFR)进行了一项全基因组关联研究(GWAS),我们在这里描述。共有8405名研究参与者聚集在4人家庭中,使用Illumina的Human 660 W-Quad阵列成功地对527,829个单核苷酸多态性(SNP)标记进行了基因分型。描述了样品和标记物的质量控制筛选以及SNP插补程序。我们还描述了祖先控制的方法,以及如何在使用快速可行的广义最小二乘算法的分析中考虑MCTFR样本的家族聚集。丰富的纵向MCTFR评估提供了许多合作机会。
As part of the Genes, Environment and Development Initiative (GEDI), the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study (GWAS), which we describe here. A total of 8405 research participants, clustered in 4-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using Illumina’s Human660W-Quad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.
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