Meta-analysis of genome-wide association studies for personality.
Meta-analysis of genome-wide association studies for personality.
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DOI：
10.1038/mp.2010.128
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发表时间：
2012-03
影响因子：
11
通讯作者：
中科院分区：
文献类型：
--
作者：
人格可以被认为是一组影响人们在各种环境中的思想，感受和行为的特征。性格的变化可以预测生活中的许多结果，包括心理健康。在这里，我们报告了10个发现样本（17375名成年人）和5个计算机模拟复制样本（3294名成年人）的全基因组关联（GWA）人格数据的荟萃分析。所有参与者都是欧洲血统。神经质、外向性、经验开放性、可信赖性和尽责性的人格得分是基于NEO五因素量表。可获得约2.4M单核苷酸多态性（SNP;直接分型并使用HAPMAP数据插补）的基因型数据。在发现样本中，在加性模型下进行经典关联分析，然后使用加权逆方差法进行荟萃分析。结果显示，在5q14.3的RASA 1基因附近（rs 1477268和rs 2032794，P = 2.8 × 10−8和3.1 × 10−8），以及在18q21.1的大脑表达的KATNAL 2基因（rs 2576037，P = 4.9 × 10−8），对经验的开放性具有全基因组意义。我们进一步进行了一项基于基因的测试，证实了KATNAL 2与尽责性的关联。然而，计算机模拟复制没有显示出顶级SNP与开放性和尽责性的显着关联，尽管KATNAL 2 SNP对尽责性的影响方向在所有复制样本中是一致的。需要更大规模的GWA研究和替代方法来确认KATNAL 2作为影响责任感的新基因。
Personality can be thought of as a set of characteristics that influence people’s thoughts, feelings, and behaviour across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in ten discovery samples (17 375 adults) and five in-silico replication samples (3 294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data were available of ~2.4M Single Nucleotide Polymorphisms (SNPs; directly typed and imputed using HAPMAP data). In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P = 2.8 × 10−8 and 3.1 × 10−8) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P = 4.9 × 10−8). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In-silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness.
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影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
17.7
作者：
Hettema, JM;Neale, MC;Kendler, KS
通讯作者：
Kendler, KS
影响因子：
0.9
作者：
Boomsma, Dorret I.;de Geus, Eco J. C.;Willemsen, Gonneke
通讯作者：
Willemsen, Gonneke
影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
9.8
作者：
Chen, Wei-Min;Abecasis, Goncalo R.
通讯作者：
Abecasis, Goncalo R.