Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.
Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.
复制标题
奖赏对小鼠浅上级丘视觉反应的调节作用。
DOI：
10.1523/jneurosci.0089-23.2023
复制
发表时间：
2023-12-13
期刊：
影响因子：
--
通讯作者：
Schröder S
中科院分区：
文献类型：
--
作者：
Baruchin LJ;Alleman M;Schröder S
感官输入的处理是不断适应行为需求和内部状态的。获得奖励的动力，例如口渴时寻找水，是一种强烈的行为需求，并将奖励与它的来源——特定的环境或行动——联系起来，这对生存至关重要。在这里，我们发现水奖励增加了上丘（SC）浅层的后续视觉活动，上丘接受来自视网膜的直接输入，属于视觉处理的最早阶段。我们训练雌雄小鼠执行一项视觉决策任务，并使用双光子钙成像和高密度电生理记录记录下SC神经元的活动。在之前的实验中，大约20%的浅表SC视觉反应神经元对视觉刺激的反应受到了奖励的影响。奖励主要增加视觉反应独立于调节瞳孔大小的变化。奖赏对视觉反应的调节不能用舔之类的动作来解释。它是特定于对接下来的视觉刺激的反应，独立于神经活动的缓慢波动，也独立于刺激之前得到奖励的频率。电生理记录证实了这些结果，并揭示了奖励在刺激开始后约80毫秒左右影响视觉反应的早期阶段。通过奖励调节视觉反应，而不是瞳孔大小，显著提高了群体解码器检测视觉刺激的表现，表明奖励调节与动物视觉表现的相关性。
The processing of sensory input is constantly adapting to behavioral demands and internal states. The drive to obtain reward, e.g., searching for water when thirsty, is a strong behavioral demand and associating the reward with its source—a certain environment or action—is paramount for survival. Here, we show that water reward increases subsequent visual activity in the superficial layers of the superior colliculus (SC), which receive direct input from the retina and belong to the earliest stages of visual processing. We trained mice of either sex to perform a visual decision task and recorded the activity of neurons in the SC using two-photon calcium imaging and high-density electrophysiological recordings. Responses to visual stimuli in around 20% of visually responsive neurons in the superficial SC were affected by reward delivered in the previous trial. Reward mostly increased visual responses independent from modulations due to pupil size changes. The modulation of visual responses by reward could not be explained by movements like licking. It was specific to responses to the following visual stimulus, independent of slow fluctuations in neural activity and independent of how often the stimulus was previously rewarded. Electrophysiological recordings confirmed these results and revealed that reward affected the early phase of the visual response around 80 ms after stimulus onset. Modulation of visual responses by reward, but not pupil size, significantly improved the performance of a population decoder to detect visual stimuli, indicating the relevance of reward modulation for the visual performance of the animal.
影响因子：
8.8
作者：
Ortiz AV;Aziz D;Hestrin S
通讯作者：
Hestrin S