Motivation and Engagement during Visually Guided Behavior.
Motivation and Engagement during Visually Guided Behavior.
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DOI：
10.1016/j.celrep.2020.108272
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发表时间：
2020-10-20
期刊：
影响因子：
8.8
通讯作者：
Hestrin S
中科院分区：
文献类型：
--
作者：
Ortiz AV;Aziz D;Hestrin S
动物行为的动机是由内部驱动，如口渴和饥饿，产生于下丘脑神经元，广泛投射到许多大脑区域。我们发现，水限制的小鼠在执行视觉任务时保持稳定，高水平的对比敏感度和短暂的反应时间，但随后突然停止并变得脱离。当在任务后立即在其家笼中自由提供时，小鼠消耗显著量的水，表明脱离接触并不反映口渴的停止。在脱离状态下，V1神经元的神经元反应降低，但瞳孔直径没有减小，这表明动物的唤醒水平降低并不驱动向脱离的过渡。我们的研究结果表明，饱足水平本身并不具有视觉引导行为的指导作用，并表明动物的行为是由成本效益分析，可以推翻口渴信号。奥尔蒂斯等人研究了小鼠在参与和脱离过程中在视觉任务中的表现。小鼠在没有达到饱足状态的情况下脱离任务。瞳孔直径表明警觉性降低与脱离无关。我们认为，视觉皮层下游的区域进行成本效益分析，管理口渴信号的反应。
Animal behavior is motivated by internal drives, such as thirst and hunger, generated in hypothalamic neurons that project widely to many brain areas. We find that water-restricted mice maintain stable, high-level contrast sensitivity and brief reaction time while performing a visual task, but then abruptly stop and become disengaged. Mice consume a significant amount of water when freely provided in their home cage immediately after the task, indicating that disengagement does not reflect cessation of thirst. Neuronal responses of V1 neurons are reduced in the disengaged state, but pupil diameter does not decrease, suggesting that animals’ reduced level of arousal does not drive the transition to disengagement. Our findings indicate that satiation level alone does not have an instructive role in visually guided behavior and suggest that animals’ behavior is governed by cost-benefit analysis that can override thirst signals. Ortiz et al. study performance of mice in a visual task during engagement and disengagement. Mice disengage from the task without reaching satiation. Pupil diameter indicates that reduced alertness is not associated with disengagement. We suggest that areas downstream of visual cortex perform cost-benefit analysis governing response to thirst signals.
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影响因子：
8.8
作者：
Burgess CP;Lak A;Steinmetz NA;Zatka-Haas P;Bai Reddy C;Jacobs EAK;Linden JF;Paton JJ;Ranson A;Schröder S;Soares S;Wells MJ;Wool LE;Harris KD;Carandini M
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16.2
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16.2
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通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
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