The ABCs of membrane transporters in health and disease (SLC series): introduction.
The ABCs of membrane transporters in health and disease (SLC series): introduction.
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DOI：
10.1016/j.mam.2012.12.009
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发表时间：
2013-04
影响因子：
10.6
通讯作者：
Bruford, Elspeth A.
中科院分区：
文献类型：
--
作者：
Hediger, Matthias A.;Clemencon, Benjamin;Burrier, Robert E.;Bruford, Elspeth A.
关键词：
在过去的十年中，转运生物学领域稳步发展，现在被认为在疾病的表现和治疗中发挥着重要作用。在人类基因组中，溶质载体基因系列已经发展到包括52个家族和395个转运基因。这些基因的列表可以在HUGO基因命名委员会（HGNC）网站上找到（见www.genenames.org/genefamilies/SLC）。这个特别的问题以每个领域的专家为每个SLC家族撰写的迷你评论为特色。现有的溶质载体在线资源Bioparadigms SLC Tables （www.bioparadigms.org）已经更新，并大量扩展了其他相关数据库的信息和交叉链接，该数据库中使用的命名法已经得到HGNC的验证和批准。此外，Bioparadigms SLC表的功能也得到了改进，以便于科学界更容易地访问。该介绍包括：所有已知的SLC和“非SLC”转运基因的概述；水溶性维生素转运体一览表；转运蛋白（包括GLUT1/SLC2A1）结构测定的最新进展综述；转运蛋白在人类疾病中的作用以及在药物批准和制药方面的作用。
The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www.genenames.org/genefamilies/SLC). This special issue features mini-reviews for each of these SLC families written by the experts in each field. The existing online resource for solute carriers, the Bioparadigms SLC Tables (www.bioparadigms.org), has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. In addition, the Bioparadigms SLC Tables functionality has been improved to allow easier access by the scientific community. This introduction includes: an overview of all known SLC and “non-SLC” transporter genes; a list of transporters of water soluble vitamins; a summary of recent progress in the structure determination of transporters (including GLUT1/SLC2A1); roles of transporters in human diseases and roles in drug approval and pharmaceutical perspectives.
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影响因子：
10.6
作者：
Franz, M-C;Anderle, P.;Buerzle, M.;Suzuki, Y.;Freeman, M. R.;Hediger, M. A.;Kovacs, G.
通讯作者：
Kovacs, G.
影响因子：
4.8
作者：
Chancy, CD;Kekuda, R;Smith, SB
通讯作者：
Smith, SB
影响因子：
13.6
作者：
Birn, H;Spiegelstein, O;Finnell, RH
通讯作者：
Finnell, RH
影响因子：
20.3
作者：
Fyfe, JC;Madsen, M;Moestrup, SK
通讯作者：
Moestrup, SK
影响因子：
20.3
作者：
Beedholm-Ebsen, Rasmus;van de Wetering, Koen;Moestrup, Soren K.
通讯作者：
Moestrup, Soren K.