In vivo experimental study of anterior cervical fusion using bioactive polyetheretherketone in a canine model.
In vivo experimental study of anterior cervical fusion using bioactive polyetheretherketone in a canine model.
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DOI：
10.1371/journal.pone.0184495
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Matsuda S
中科院分区：
文献类型：
--
作者：
Shimizu T;Fujibayashi S;Yamaguchi S;Otsuki B;Okuzu Y;Matsushita T;Kokubo T;Matsuda S
聚醚醚酮（PEEK）是一种被广泛接受的生物材料，特别是在脊柱外科领域。然而，由于其生物惰性，PEEK不能直接与骨组织结合。为了克服这一缺点，各种研究已经描述了旨在增加PEEK表面生物活性的表面涂层方法。其中，最近开发的溶胶-凝胶TiO2涂层可以在不使用骨移植的情况下为PEEK提供与骨组织结合的能力。这项犬体内实验研究确定了生物活性二氧化钛包覆PEEK对颈椎前路融合的疗效。溶胶-凝胶衍生的二氧化钛涂层，包括喷砂和酸处理，被用来给PEEK骨粘合能力。采用生物活性二氧化钛包覆聚醚醚酮制备了适合小猎犬椎间盘间隙的颈椎椎间间隔器。将未涂覆PEEK（对照组）和二氧化钛涂覆PEEK垫片植入比格犬的颈椎间隙（每种n = 5）。在3个月的生存期后，通过μ-CT成像、组织学和手触诊分析评估体间融合成功与否。手工触诊分析显示，二氧化钛涂层PEEK组的融合率为60%（3/5例）（骨与种植体之间无间隙），明显优于未涂层PEEK组的0%（0/5例）融合率。μCT显像显示，二氧化钛包覆PEEK组骨融合率为40%；然而，未涂覆PEEK组为0%。此外，使用组织形态测量法计算的骨-种植体接触比表明，二氧化钛涂层PEEK组比未涂层PEEK组的接触比更好（平均32.6% vs 3.2%; p = 0.017）。在犬颈椎前路融合模型中，二氧化钛包被的生物活性PEEK植入物比未包被的PEEK植入物表现出更好的融合率和骨结合能力。生物活性PEEK具有骨结合能力，有助于进一步改善脊柱椎体间融合的临床结果。
Polyetheretherketone (PEEK) is a widely accepted biomaterial, especially in the field of spinal surgery. However, PEEK is not able to directly integrate with bone tissue, due to its bioinertness. To overcome this drawback, various studies have described surface coating approaches aimed at increasing the bioactivity of PEEK surfaces. Among those, it has been shown that the recently developed sol-gel TiO2 coating could provide PEEK with the ability to bond with bone tissue in vivo without the use of a bone graft. This in vivo experimental study using a canine model determined the efficacy of bioactive TiO2-coated PEEK for anterior cervical fusion. Sol-gel–derived TiO2 coating, which involves sandblasting and acid treatment, was used to give PEEK bone-bonding ability. The cervical interbody spacer, which was designed to fit the disc space of a beagle, was fabricated using bioactive TiO2-coated PEEK. Both uncoated PEEK (control) and TiO2-coated PEEK spacers were implanted into the cervical intervertebral space of beagles (n = 5 for each type). After the 3-month survival period, interbody fusion success was evaluated based on μ-CT imaging, histology, and manual palpation analyses. Manual palpation analyses indicated a 60% (3/5 cases) fusion (no gap between bone and implants) rate for the TiO2-coated PEEK group, indicating clear advantage over the 0% (0/5 cases) fusion rate for the uncoated PEEK group. The bony fusion rate of the TiO2-coated PEEK group was 40% according to μCT imaging; however, it was 0% of for the uncoated PEEK group. Additionally, the bone–implant contact ratio calculated using histomorphometry demonstrated a better contact ratio for the TiO2-coated PEEK group than for the uncoated PEEK group (mean, 32.6% vs 3.2%; p = 0.017). The TiO2-coated bioactive PEEK implant demonstrated better fusion rates and bone-bonding ability than did the uncoated PEEK implant in the canine anterior cervical fusion model. Bioactive PEEK, which has bone-bonding ability, could contribute to further improvements in clinical outcomes for spinal interbody fusion.
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影响因子：
1.8
作者：
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