Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.

Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.
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减数分裂 I 期间的染色体分离需要秀丽隐杆线虫后期促进复合体的多个亚基。

DOI:
10.1093/genetics/160.2.805
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发表时间:
2002
期刊:
影响因子:
3.3
通讯作者:
Golden,Andy
Golden,Andy
中科院分区:
生物学2区
文献类型:
--
作者:
Davis,EdwardS;Wille,Lucia;Chestnut,BarryA;Sadler,PennyL;Shakes,DianeC;Golden,Andy

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最初在减数分裂 I 中期停滞的秀丽隐杆线虫突变体的遗传筛选中发现的两个基因,被证明编码后期促进复合体或环体 (APC/C) 的亚基。 RNA 干扰研究表明,这些亚基和其他 APC/C 亚基对于减数分裂 I 期间染色体同源物的分离至关重要。此外,减数分裂 I 期间的染色体分离除了释放姐妹染色单体凝聚力之外还需要 APC/C 功能。
Two genes, originally identified in genetic screens forCaenorhabditis elegansmutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.
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