Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction.
Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction.
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DOI：
10.1016/j.brainres.2010.10.052
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发表时间：
2011-01-12
期刊：
影响因子：
2.9
通讯作者：
Shapiro SM
中科院分区：
文献类型：
--
作者：
Rice AC;Chiou VL;Zuckoff SB;Shapiro SM
Excessive hyperbilirubinemia in human neonates can cause permanent dysfunction of the auditory system, as assessed with brainstem auditory evoked potentials (BAEPs). Jaundiced Gunn rat pups (jjs) exhibit similar BAEP abnormalities as hyperbilirubinemic neonates. Sulfadimethoxine (sulfa) administration to jjs, which displaces bilirubin from serum albumin into tissues including brain, exacerbates acute toxicity. Minocycline administered prior to sulfa in jjs protects against BAEP abnormalities. This study evaluates the neuroprotective capabilities of minocycline HCl (50mg/kg) administered 30 or 120min after sulfa (200mg/kg) in 16 day old jjs. BAEPs are recorded at 6 or 24hr post-sulfa. Abnormal BAEP waves exhibit increased latency and decreased amplitude. The sulfa/saline treated jjs exhibited a significantly increased interwave interval between waves I and II (I–II IWI) and significantly decreased amplitudes of waves II and III compared to the saline/saline jjs. The minocycline 30min post-sulfa (sulfa/mino +30) group was not significantly different from the saline/saline control group, indicating neuroprotection. The minocycline 120min post-sulfa (sulfa/mino+120) group had a significantly decreased amplitude of wave III at both 6 and 24hr. These studies indicate that minocycline has a graded neuroprotective effect when administered after acute bilirubin neurotoxicity.
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DOI：
10.1177/1470320309343007
发表时间：
2009-12-01
影响因子：
2.9
作者：
Hoi-Hansen, Thomas;Pedersen-Bjergaard, Ulrik;Thorsteinsson, Birger
通讯作者：
Thorsteinsson, Birger
影响因子：
56.9
作者：
BUCHWALD, JS;HUANG, CM
通讯作者：
HUANG, CM
影响因子：
2.5
作者：
Geiger, Angela S.;Rice, Ann C.;Shapiro, Steven M.
通讯作者：
Shapiro, Steven M.
DOI：
10.1001/archpedi.1961.04020040050007
发表时间：
1961-01-01
影响因子：
--
作者：
JOHNSON, L;SARMIENTO, F;FIGUEROA, E
通讯作者：
FIGUEROA, E
影响因子：
4.8
作者：
Mejia, ROS;Ona, VO;Friedlander, RM
通讯作者：
Friedlander, RM