Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.
Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.
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双相情感障碍昼夜节律紊乱的神经生物学和行为机制：ISBD时间生物学工作组未来研究的重要多学科文献回顾和议程。
DOI：
10.1111/bdi.13165
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发表时间：
2022-05
影响因子：
5.4
通讯作者：
Murray, Greg
中科院分区：
文献类型：
--
作者：
McCarthy, Michael J.;Gottlieb, John F.;Gonzalez, Robert;McClung, Colleen A.;Alloy, Lauren B.;Cain, Sean;Dulcis, Davide;Etain, Bruno;Frey, Benicio N.;Garbazza, Corrado;Ketchesin, Kyle D.;Landgraf, Dominic;Lee, Heon-Jeong;Marie-Claire, Cynthia;Nusslock, Robin;Porcu, Alessandra;Porter, Richard;Ritter, Philipp;Scott, Jan;Smith, Daniel;Swartz, Holly A.;Murray, Greg
关键词：
双相情感障碍的症状包括情绪、活动、精力、睡眠和食欲的改变。由于这些过程中的许多是由昼夜节律功能调节的，昼夜节律紊乱被认为是BD的一个生物学特征。国际双相情感障碍协会时间生物学工作组(CTF)被委托审查与BD相关的神经生物学和行为机制的证据。利用动物模型、生物标记物、生理学和行为学方面的专业知识，CTF分析了相关的跨学科文献，以准确地框架围绕BD昼夜节律紊乱的讨论，突出关键发现，并首次整合不同分析水平的发现，以开发内部一致、连贯的理论框架。来自多个来源的证据表明，昼夜节律系统与情绪调节有关，与BD诊断和报告的跨遗传、细胞、生理和行为领域的情绪相关特征有相应的关联。然而，昼夜节律紊乱似乎并不是BD所特有的，它存在于各种高危、前驱症状和综合征精神障碍中。这项研究所依据的定义、概念和假设之间存在很大的可变性和模糊性，限制了复制和出现协商一致的结论。未来对昼夜节律及其在BD中的作用的研究是有必要的。仔细定义BD相关结构和时间生物学相关结构之间的关联，并跨分析水平整合的强大研究将是最具启发性的。
Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD. Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross‐disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework. Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood‐related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high‐risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings. Future research in circadian rhythms and its role in BD is warranted. Well‐powered studies that carefully define associations between BD‐related and chronobiologically‐related constructs, and integrate across levels of analysis will be most illuminating.
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影响因子：
4.6
作者：
Alloy LB;Boland EM;Ng TH;Whitehouse WG;Abramson LY
通讯作者：
Abramson LY
影响因子：
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作者：
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DOI：
10.1073/pnas.1424958112
发表时间：
2015-03-17
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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