Cascades of transcription regulation during liver regeneration.
Cascades of transcription regulation during liver regeneration.
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DOI：
10.1016/j.biocel.2010.03.013
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发表时间：
2011-02
影响因子：
4
通讯作者：
Barton, Michelle Craig
中科院分区：
文献类型：
--
作者：
Kurinna, Svitlana;Barton, Michelle Craig
对癌症预防和再生医学新策略的需求日益增加，需要更好地了解以组织特异性方式控制细胞增殖的分子机制。再生肝脏是一种独特的模型，允许使用生化，遗传和工程工具来揭示分子机制并改善肝癌，肝衰竭和纤维化疾病的治疗。肝再生的分子机制涉及细胞外和细胞内因子，以激活通常在静止肝脏中沉默的基因的转录。虽然再生肝脏的许多上游信号通路已被广泛研究，但我们对下游效应子转录因子（TF）的了解仍然有限。这篇综述描述了连续参与预先存在的和从头合成的TF，作为级联调节生长相关和代谢基因的表达在小鼠部分肝切除术后的肝再生过程中。几个以前公认的调节再生肝脏的最近确定的辅激活剂和辅阻遏物复合物与主要的DNA结合TF相互作用的光中描述。已发表的基因表达和染色质免疫沉淀分析结果，以及转基因小鼠模型的研究，被用来强调新的潜在的调控转录在肝再生。最后，更详细地描述了新发现的肝再生的转录调节因子，说明了部分肝切除术后增殖和代谢反应的严格调节平衡。
An increasing demand for new strategies in cancer prevention and regenerative medicine requires a better understanding of molecular mechanisms that control cell proliferation in tissue-specific manner. Regenerating liver is a unique model allowing use of biochemical, genetic, and engineering tools to uncover molecular mechanisms and improve treatment of hepatic cancers, liver failure, and fibrotic disease. Molecular mechanisms of liver regeneration involve extra- and intracellular factors to activate transcription of genes normally silenced in quiescent liver. While many upstream signaling pathways of the regenerating liver have been extensively studied, our knowledge of the downstream effectors, transcription factors (TFs), remains limited. This review describes consecutive engagement of pre-existing and de novo synthesized TFs, as cascades that regulate expression of growth-related and metabolic genes during liver regeneration after partial hepatectomy in mice. Several previously recognized regulators of regenerating liver are described in the light of recently identified co-activator and co-repressor complexes that interact with primary DNA-binding TFs. Published results of gene expression and chromatin immunoprecipitation analyses, as well as studies of transgenic mouse models, are used to emphasize new potential regulators of transcription during liver regeneration. Finally, a more detailed description of newly identified transcriptional regulators of liver regeneration illustrates the tightly regulated balance of proliferative and metabolic responses to partial hepatectomy.
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DOI：
10.1073/pnas.84.10.3161
发表时间：
1987-05-01
影响因子：
11.1
作者：
BHAT, NK;FISHER, RJ;PAPAS, TS
通讯作者：
PAPAS, TS
影响因子：
11.4
作者：
Behrens, A;Sibilia, M;Wagner, EF
通讯作者：
Wagner, EF
影响因子：
13.5
作者：
Gkretsi, Vasiliki;Apte, Udayan;Mars, Wendy M.;Bowen, William C.;Luo, Jian-Hua;Yang, Yu;Yu, Yan P.;Orr, Ann;St-Arnaud, Rene;Dedhar, Shoukat;Kaestner, Klaus H.;Wu, Chuanyue;Michalopoulos, George K.
通讯作者：
Michalopoulos, George K.
影响因子：
64.5
作者：
Goessling W;North TE;Loewer S;Lord AM;Lee S;Stoick-Cooper CL;Weidinger G;Puder M;Daley GQ;Moon RT;Zon LI
通讯作者：
Zon LI
影响因子：
3.5
作者：
Choi, JH;Park, MJ;Cheong, J
通讯作者：
Cheong, J