Order through destruction: how ER-associated protein degradation contributes to organelle homeostasis.
Order through destruction: how ER-associated protein degradation contributes to organelle homeostasis.
复制标题
通过破坏的顺序：与ER相关的蛋白质降解如何有助于细胞器稳态。
DOI：
10.15252/embj.2021109845
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发表时间：
2022-03-15
期刊：
影响因子：
--
通讯作者：
Carvalho P
中科院分区：
文献类型：
--
作者：
Christianson JC;Carvalho P
内质网是一个巨大的、动态的、多功能的细胞器。ER蛋白稳态对于协调其多种功能至关重要，并依赖于ER相关蛋白降解（ERAD）。后一个过程选择ER的内腔和膜中的靶蛋白，促进它们的泛素化，并促进它们递送到细胞溶质中以供蛋白酶体降解。ERAD最初以降解错误折叠蛋白质和甾醇生物合成限速酶的作用为特征，现在ERAD的许多分支似乎控制更广泛底物的水平，并更广泛地影响ER的组织和功能，以及其与相邻细胞器的相互作用。在这里，我们讨论了最近的机械进展，我们的理解ERAD及其后果的调节ER功能。Christianson和Carvalho回顾了ERAD的机制和作用，从蛋白质质量控制和甾醇生物合成调节的原始含义到塑造ER及其与其他隔室相互作用的新兴功能。
The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER protein homeostasis is essential for the coordination of its diverse functions and depends on ER‐associated protein degradation (ERAD). The latter process selects target proteins in the lumen and membrane of the ER, promotes their ubiquitination, and facilitates their delivery into the cytosol for degradation by the proteasome. Originally characterized for a role in the degradation of misfolded proteins and rate‐limiting enzymes of sterol biosynthesis, the many branches of ERAD now appear to control the levels of a wider range of substrates and influence more broadly the organization and functions of the ER, as well as its interactions with adjacent organelles. Here, we discuss recent mechanistic advances in our understanding of ERAD and of its consequences for the regulation of ER functions. Christianson and Carvalho review the mechanisms and roles of ERAD, from original implications in protein quality control and sterol biosynthesis regulation to emerging functions in shaping the ER and its interactions with other compartments.
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