Patterns of use and survival outcomes of positron emission tomography for initial staging in elderly follicular lymphoma patients.
Patterns of use and survival outcomes of positron emission tomography for initial staging in elderly follicular lymphoma patients.
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DOI：
10.1080/10428194.2016.1253836
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发表时间：
2017-07
影响因子：
2.6
通讯作者：
Flowers CR
中科院分区：
文献类型：
--
作者：
Rai A;Nastoupil LJ;Williams JN;Lipscomb J;Ward KC;Howard DH;Lee D;Flowers CR
正电子发射断层扫描 (PET) 在滤泡性淋巴瘤 (FL) 初步评估中的作用一直是一个争论话题。我们研究了 FL 中 PET 分期的使用模式，并评估了 PET 与生存率的关系。使用 SEER-Medicare 数据库，我们确定了 2000 年至 2009 年间诊断出首次原发性 FL 的 5,712 名患者。年龄较大、非洲裔美国人、体力状况不佳、B 症状和贫血病史与 PET 分期呈负相关。接受 PET 分期与在研究网络附属机构的治疗以及居住在核医学专家较集中的地区呈正相关。 PET 与改善淋巴瘤相关 [HR 0.69，95% CI 0.58-0.82] 和总体 [HR 0.75，95% CI 0.68-0.83] 生存率相关。我们的研究结果证实了 PET 可以作为 FL 患者成像的标准治疗方法。需要进一步研究以确定与 FL PET 分期相关的明显生存优势的机制。
The role of positron emission tomography (PET) in the initial assessment of follicular lymphoma (FL) has been a topic of debate. We examined the patterns of utilization of PET-staging in FL and assessed the association of PET with survival. Using the SEER-Medicare database, we identified 5,712 patients diagnosed with first primary FL between 2000 and 2009. Older age, African-American race, poor performance status, B-symptoms, and history of anemia were negatively associated with PET-staging. Receipt of PET-staging was positively associated with treatment at institutions affiliated with research networks and with residence in areas with higher concentrations of nuclear medicine specialists. PET was associated with improved lymphoma-related [HR 0.69, 95% CI 0.58-0.82] and overall [HR 0.75, 95% CI 0.68-0.83) survival. Our findings substantiate the use of PET as the standard-of-care for imaging in FL patients. Further investigation is warranted to identify mechanisms underlying the apparent survival advantage associated with PET-staging in FL.
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Link, Brian K.
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作者：
Ambinder, Alexander J;Shenoy, Pareen J;Flowers, Christopher R
通讯作者：
Flowers, Christopher R