Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning.
Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning.
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DOI：
10.1016/j.celrep.2018.04.081
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发表时间：
2018-05-22
期刊：
影响因子：
8.8
通讯作者：
Holmes A
中科院分区：
文献类型：
--
作者：
Bergstrom HC;Lipkin AM;Lieberman AG;Pinard CR;Gunduz-Cinar O;Brockway ET;Taylor WW;Nonaka M;Bukalo O;Wills TA;Rubio FJ;Li X;Pickens CL;Winder DG;Holmes A
在当前的模型中，学习环境刺激和行动结果之间的关系涉及刺激驱动和目标导向系统，分别由DLS和DMS介导。然而，尽管这些模型强调了DLS在积累了大量经验后在治理行动中的重要性，但越来越多的证据表明，DLS从培训开始就参与其中。在这里，我们使用体内光沉默来揭示DLS招募干扰早期触摸屏辨别学习。我们还表明，DLS的直接输出途径优先招募和因果关系参与早期学习，并发现沉默的DLS的正常贡献产生可塑性相关的改变在PL-DMS电路。这些数据提供了进一步的证据表明，DLS被招募在刺激引发的行动，最终自动化的行为和解放认知资源的其他需求，但在学习开始时的性能成本的建设。DLS在早期辨别学习中有何贡献？Bergstrom等人使用体内光遗传学、荧光原位杂交和全脑活动映射显示，沉默DLS促进早期辨别学习，驱动平行PL-DMS回路中的活动，并优先募集DLS“直接”输出途径。
In current models, learning the relationship between environmental stimuli and the outcomes of actions involves both stimulus-driven and goal-directed systems, mediated in part by the DLS and DMS, respectively. However, though these models emphasize the importance of the DLS in governing actions after extensive experience has accumulated, there is growing evidence of DLS engagement from the onset of training. Here, we used in vivo photosilencing to reveal that DLS recruitment interferes with early touchscreen discrimination learning. We also show that the direct output pathway of the DLS is preferentially recruited and causally involved in early learning and find that silencing the normal contribution of the DLS produces plasticity-related alterations in a PL-DMS circuit. These data provide further evidence suggesting that the DLS is recruited in the construction of stimulus-elicited actions that ultimately automate behavior and liberate cognitive resources for other demands, but with a cost to performance at the outset of learning. What is the contribution of the DLS in early discrimination learning? Bergstrom et al. show using in vivo optogenetics, fluorescence in situ hybridization, and brain-wide activity mapping that silencing the DLS facilitates early discrimination learning, drives activity in a parallel PL-DMS circuit, and preferentially recruits the DLS “direct” output pathway.
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DOI：
10.1196/annals.1390.006
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
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作者：
Balleine, Bernard W.;Ostlund, Sean B.
通讯作者：
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DOI：
10.1037/a0030941
发表时间：
2013-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
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作者：
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通讯作者：
Balleine, Bernard W.
影响因子：
5.3
作者：
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通讯作者：
Jung, Min Whan
DOI：
10.1073/pnas.1308198110
发表时间：
2013-09-03
影响因子：
11.1
作者：
DePoy, Lauren;Daut, Rachel;Holmes, Andrew
通讯作者：
Holmes, Andrew
影响因子：
64.8
作者：
Komiyama, Takaki;Sato, Takashi R.;Svoboda, Karel
通讯作者：
Svoboda, Karel