N-acetyl-aspartylglutamate: binding sites and excitatory action in the dorsolateral septum of rats
N-acetyl-aspartylglutamate: binding sites and excitatory action in the dorsolateral septum of rats
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N-乙酰-天冬氨酰谷氨酸：大鼠背外侧隔膜的结合位点和兴奋作用
DOI：
10.1016/0006-8993(87)90144-2
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发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
E. R. Kloet
中科院分区：
文献类型：
--
作者：
M. Joe¨ls;M. V. Veldhuizen;I. Urban;E. R. Kloet
In this study we examined the distribution of binding sites for[3H]N-acetyl-aspartylglutamate(NAAG) in the rat lateral septal nucleus (LSN) and the effect of iontophoretically applied NAAG on neuronal firing in this area. A high density of [3H]NAAG binding sites was found in the dorsolateral part of the LSN. Binding in the intermediate/ventral part of the LSN and medial septum was less denses. NAAG excited 75% of the dorsal neurons in the LSN, but only 36% of the cells in the intermediate/ventral part. Glutamic diethylester, an amino acid antagonist, depressed responses to NAAG to a similar extent as responses to quaiqualate. The antagonist amino phosphonovaleric acid, which suppressed responses to N-methyl-d-aspartate almost completely, reduced NAAG-evoked responses only by 40%. A possible role of NAAG as excitatory transmitter in the LSN is discussed.
N-乙酰基-天冬氨酰-谷氨酸与[3H]L-谷氨酸受体相互作用的表征。
影响因子：
5
作者：
Koller,KJ;Coyle,JT
通讯作者：
Coyle,JT
用 [3H]N-乙酰基-天冬氨酰-谷氨酸对脑受体进行特异性标记。
影响因子：
5
作者：
Koller,KJ;Coyle,JT
通讯作者：
Coyle,JT