Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat
Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat
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肌肽（组氨酸的前体）可改善戊四唑诱导的大鼠癫痫发作
DOI：
10.1016/j.neulet.2006.02.031
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发表时间：
2006-05
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
肌肽（β-丙氨酰-L-组氨酸）已被表征为推定的神经递质。然而，到目前为止，对肌肽在大脑中的作用的了解非常有限。本研究的目的是研究肌肽对戊四氮（PTZ）点燃癫痫发作的影响和对PTZ点燃癫痫发作的保护作用。腹腔注射戊四氮（PTZ）35 mg/kg，每48 h重复1次，直至出现4-5期癫痫发作，记录点燃发作活动30 min。在急性戊四氮激发研究中，使用60 mg/kg戊四氮诱导点燃癫痫发作。注射肌肽（200、500 mg/kg，i. p.）以剂量和时间依赖性方式显著降低癫痫发作阶段，延长肌阵挛性痉挛的潜伏期。在癫痫发作的发展过程中，500 mg/kg肌肽也明显延迟PTZ点燃癫痫发作。此外，肌肽显著逆转了海马中PTZ点燃癫痫发作诱导的组胺水平降低。这些结果表明，肌肽可以保护对戊四氮诱导的癫痫发作的发展点燃和挑战过程中的大鼠。结果提示肌肽可能是脑内的一种内源性抗惊厥因子，有望成为一种新的抗癫痫药物。
Carnosine (β-alanyl-l-histidine) has been characterized as a putative neurotransmitter. However, so far, understanding of the role of carnosine in the brain is very limited. The objective of this study was to examine the effects of carnosine on the development of pentylenetetrazol (PTZ) kindling seizures and protection against the PTZ kindled seizures in rats. Chemical kindling was elicited by repeated intraperitoneal injection of PTZ (35mg/kg) once every 48h until the occurrence of Stage 4–5 seizures, and the seizure activity of kindling was recorded for 30min. In an acute PTZ challenge study, 60mg/kg PTZ was used to induce kindled seizure. Injection of carnosine (200, 500mg/kg, i.p.) significantly decreased seizure stage, and prolonged the latencies for myoclonic jerks, in a dose- and time-dependent manner. In the seizure development process, 500mg/kg carnosine also significantly delayed the onset of PTZ kindled seizures. In addition, carnosine significantly reversed decreased histamine levels induced by PTZ kindled seizure in the hippocampus. These results indicate that carnosine can protect against PTZ-induced seizures in both the development of kindling and the challenge process in rats. The results suggest that carnosine might be an endogenous anticonvulsant factor in the brain and can be used as a new antiepileptic drug in future.
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影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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通讯作者：
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