Incidence of multiple primary cancers and interval between first and second primary cancers.
Incidence of multiple primary cancers and interval between first and second primary cancers.
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DOI：
10.1111/cas.12433
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发表时间：
2014-07
期刊：
影响因子：
5.7
通讯作者：
Soda M
中科院分区：
文献类型：
--
作者：
Utada M;Ohno Y;Hori M;Soda M
在这项回顾性研究中，我们的目的是澄清发生第二原发癌的风险，并确定第二原发癌的高风险时期。研究对象是1985年至2007年间在长崎县癌症登记处登记的所有被诊断为第一原发性癌症的患者。我们计算了标准化发病率（SIR）的第二原发癌根据部位和年后的第一原发癌的诊断。在中位1.8年的随访期间，174 477名受试者中有14 167名（8.1%）发生了第二原发癌症。所有癌症的SIR为1.10（95%可信区间为1.08-1.11）。一些特定的关系被观察到有共同危险因素的部位，如吸烟、饮酒和激素状态。大约10年后，所有癌症部位的SIRs都相对较高，不同癌症部位的趋势有所不同。我们发现癌症患者患第二原发癌症的风险高于一般人群。在患第二原发癌的风险方面，医生应警惕与第一原发癌有共同风险因素的癌症。
In this retrospective study, we aimed to clarify the risk of developing a second primary cancer and to determine the periods of high risk of second primary cancers. Subjects were all patients who had been diagnosed with a first primary cancer and registered with the Nagasaki Prefecture Cancer Registry between 1985 and 2007. We calculated the standardized incidence ratio (SIR) of second primary cancer according to site and years after diagnosis of the first primary cancer. A second primary cancer developed in 14 167 of 174 477 subjects (8.1%) during a median follow-up of 1.8 years. The SIR of all cancer was 1.10 (95% confidence interval, 1.08–1.11). Some specific relationships were observed between sites with risk factors in common, such as smoking, drinking, and hormone status. The SIRs were relatively high after approximately 10 years for all sites, and trends differ among cancer sites. We showed that cancer patients are at higher risk of a second primary cancer than the general population. In respect of the risk of a second primary cancer, physicians should be alert for cancers that have risk factors in common with the first primary cancer.
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影响因子：
8.4
作者：
Filali, K;Hedelin, G;Torhorst, J
通讯作者：
Torhorst, J
DOI：
10.1111/j.1349-7006.1993.tb02018.x
发表时间：
1993-06-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
GAO, CM;TAJIMA, K;INOUE, M
通讯作者：
INOUE, M
DOI：
10.1111/j.1349-7006.1992.tb00111.x
发表时间：
1992-04-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
HIYAMA, T;SATO, T;FUJIMOTO, I
通讯作者：
FUJIMOTO, I
影响因子：
3.3
作者：
Rosso S;Terracini L;Ricceri F;Zanetti R
通讯作者：
Zanetti R
影响因子：
5.7
作者：
Tabuchi, Takahiro;Ito, Yuri;Tsukuma, Hideaki
通讯作者：
Tsukuma, Hideaki