Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood.
Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood.
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DOI：
10.1111/jsr.12427
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发表时间：
2016-12
影响因子：
4.4
通讯作者：
LeBourgeois MK
中科院分区：
文献类型：
--
作者：
Kurth S;Lassonde JM;Pierpoint LA;Rusterholz T;Jenni OG;McClain IJ;Achermann P;LeBourgeois MK
虽然所有的幼儿都会午睡，但白天睡眠的神经生理学特征和相关的发展轨迹在很大程度上仍然未知。午睡生理学的纵向研究是了解儿童早期睡眠调节的基础，这是大脑和行为发育的敏感时期，也是儿童从双相睡眠-觉醒模式过渡到双相睡眠-觉醒模式的时期。我们调查了8名健康儿童的白天睡眠，在三个纵向点进行睡眠脑电图（EEG）评估：2年（2.5-3.0岁），3年（3.5-4.0岁）和5年（5.5-6.0岁）。在每个年龄段，我们在三个随机条件下测量午睡脑电图：4小时（上午午睡），7小时（下午午睡）和10小时（晚上午睡）的持续时间之前的觉醒。睡眠的发育变化在午睡中最为普遍（例如，2至3岁的睡眠时间减少30分钟，3至5岁的睡眠时间减少20分钟）。相反，午睡睡眠结构（睡眠阶段的百分比）在不同年龄段保持不变。在慢波活动（SWA，0.75-4.5 Hz）、θ（4.75-7.75 Hz）和σ（10-15 Hz）频率范围内，非快速眼动睡眠EEG功率的成熟变化是明显的。这些发现表明，随着儿童的成熟，睡眠深度的主要标志物SWA在白天小睡时不那么明显。此外，我们的基础数据提供了对儿童早期睡眠调节与中枢神经系统功能改变之间关系的深入了解。
Although all young children nap, the neurophysiological features and associated developmental trajectories of daytime sleep remain largely unknown. Longitudinal studies of napping physiology are fundamental to understanding sleep regulation during early childhood, a sensitive period in brain and behaviour development and a time when children transition from a biphasic to a monophasic sleep–wakefulness pattern. We investigated daytime sleep in eight healthy children with sleep electroencephalography (EEG) assessments at three longitudinal points: 2 years (2.5–3.0 years), 3 years (3.5–4.0 years) and 5 years (5.5–6.0 years). At each age, we measured nap EEG during three randomized conditions: after 4 h (morning nap), 7 h (afternoon nap) and 10 h (evening nap) duration of prior wakefulness. Developmental changes in sleep were most prevalent in the afternoon nap (e.g. decrease in sleep duration by 30 min from 2 to 3 years and by 20 min from 3 to 5 years). In contrast, nap sleep architecture (% of sleep stages) remained unchanged across age. Maturational changes in non-rapid eye movement sleep EEG power were pronounced in the slow wave activity (SWA, 0.75–4.5 Hz), theta (4.75–7.75 Hz) and sigma (10–15 Hz) frequency ranges. These findings indicate that the primary marker of sleep depth, SWA, is less apparent in daytime naps as children mature. Moreover, our fundamental data provide insight into associations between sleep regulation and functional modifications in the central nervous system during early childhood.
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影响因子：
4.4
作者：
Berger RH;Miller AL;Seifer R;Cares SR;LeBourgeois MK
通讯作者：
LeBourgeois MK
影响因子：
3.3
作者：
Doucette, Margaret R.;Kurth, Salome;LeBourgeois, Monique K.
通讯作者：
LeBourgeois, Monique K.
影响因子：
3.5
作者：
DIJK D J;BEERSMA D G M;DAAN S
通讯作者：
DAAN S
影响因子：
--
作者：
ALFOLDI, P;TOBLER, I;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
2.2
作者：
ANDERS, TF;ROFFWARG, HP
通讯作者：
ROFFWARG, HP