The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells.
The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells.
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铁死亡诱导剂erastin促进人外周血单个核细胞增殖和分化
DOI：
10.1016/j.bbrc.2018.07.100
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发表时间：
2018-09-10
影响因子：
3.1
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Wang D;Xie N;Gao W;Kang R;Tang D
外周血单个核细胞（PBMC）含有多能祖细胞群，并具有在生理和病理条件下分化为各种类型的免疫细胞的潜力。铁凋亡是一种氧化应激相关的细胞死亡，主要由脂质过氧化介导。然而，铁凋亡在细胞分化中的功能仍然未知。在这里，我们发现铁凋亡诱导剂erastin不会导致人PBMC中的细胞死亡。相反，erastin诱导的脂质过氧化通过抑制骨形态发生蛋白家族表达促进人PBMC增殖和分化为B细胞和自然杀伤细胞。这些发现揭示了erastin促进PBMC增殖和分化的新的免疫调节功能。
Peripheral blood mononuclear cells (PBMCs) contain multipotent progenitor cell populations and possess the potential to differentiate into various types of immune cells under both physiological and pathological conditions. Ferroptosis is a type of oxidative stress-associated cell death that is mainly mediated by lipid peroxidation. However, the function of ferroptosis in cell differentiation remains unknown. Here, we showed that the ferroptosis inducer erastin did not cause cell death in human PBMCs. In contrast, erastin-induced lipid peroxidation promoted human PBMC proliferation and differentiation into B cells and natural killer cells through inhibition of bone morphogenetic protein family expression. These findings uncover a new immune modulation function of erastin in promoting PBMC proliferation and differentiation.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
3.6
作者：
Liguori I;Russo G;Curcio F;Bulli G;Aran L;Della-Morte D;Gargiulo G;Testa G;Cacciatore F;Bonaduce D;Abete P
通讯作者：
Abete P
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
16
作者：
Kroemer G;Mariño G;Levine B
通讯作者：
Levine B
影响因子：
5.4
作者：
Martinez, Victor G.;Hidalgo, Laura;Varas, Alberto
通讯作者：
Varas, Alberto