White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: a diffusion tensor imaging study.
White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: a diffusion tensor imaging study.
复制标题
1型肌营养不良症儿童和青少年的白质异常和神经认知相关性：弥散张量成像研究。
DOI：
10.1016/j.nmd.2010.11.013
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发表时间：
2011-02
影响因子：
2.8
通讯作者：
Day, John W.
中科院分区：
文献类型：
--
作者：
Wozniak, Jeffrey R.;Mueller, Bryon A.;Ward, Erin E.;Lim, Kelvin O.;Day, John W.
Diffusion Tensor Imaging was used to evaluate cerebral white matter in eight patients (ages 10–17) with myotonic dystrophy type 1 (3 congenital-onset, 5 juvenile-onset) compared to eight controls matched for age and sex. Four regions of interest were examined: inferior frontal, superior frontal, supracallosal, and occipital. The myotonic dystrophy group showed white matter abnormalities compared to controls in all regions. All indices of white matter integrity were abnormal: fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. With no evidence of regional variation, correlations between whole cerebrum white matter fractional anisotropy and neurocognitive functioning were examined in the patients. Strong correlations were observed between whole cerebrum fractional anisotropy and full-scale intelligence and a measure of executive functioning. Results indicate that significant white matter abnormality is characteristic of young patients with myotonic dystrophy type 1 and that the white matter abnormality seen with neuroimaging has implications for cognitive functioning.
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影响因子：
--
作者：
GLANTZ, RH;WRIGHT, RB;SIEGEL, IM
通讯作者：
SIEGEL, IM
影响因子：
2.8
作者：
Di Costanzo, A;Di Salle, F;Tedeschi, G
通讯作者：
Tedeschi, G
影响因子：
3.8
作者：
GARCIAALIX, A;CABANAS, F;QUERO, J
通讯作者：
QUERO, J
影响因子：
11
作者：
Antonini, G;Mainero, C;Caramia, F
通讯作者：
Caramia, F
影响因子：
3.5
作者：
Jiang, H;Mankodi, A;Thornton, CA
通讯作者：
Thornton, CA