Mechanobiology of YAP and TAZ in physiology and disease.
Mechanobiology of YAP and TAZ in physiology and disease.
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YAP和TAZ的机械生物学在生理和疾病中。
DOI：
10.1038/nrm.2017.87
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Piccolo S
中科院分区：
文献类型：
--
作者：
Panciera T;Azzolin L;Cordenonsi M;Piccolo S
越来越多的证据表明，细胞微环境发出的机械信号是细胞行为的基本调节因素。此外，在宏观尺度上，力的影响，如血液流动和肌肉收缩产生的力、重力以及整体组织刚性(例如肿块内部)是我们理解生理和疾病发病机制的核心。然而，机械信号是如何在分子水平上被感知和转换以调节基因表达的，长期以来一直是个谜。转录因子YAP和TAZ的发现填补了这一空白。YAP和TAZ阅读广泛的机械信号，从剪切力到细胞形状和细胞外基质刚性，并将它们翻译成细胞特有的转录程序。YAP和TAZ的机械转导对推动干细胞行为和再生至关重要，并揭示了异常的细胞力学有助于多种疾病的发病机制，如动脉粥样硬化、纤维化、肺动脉高压、炎症、肌肉营养不良和癌症。
A growing body of evidence suggests that mechanical signals emanating from the cell's microenvironment are fundamental regulators of cell behaviour. Moreover, at the macroscopic scale, the influence of forces, such as the ones generated by blood flow and muscle contraction, gravity, as well as overall tissue rigidity (for example inside of a tumor lump) are central to our understanding of physiology and disease pathogenesis. And yet, how mechanical cues are sensed and transduced at the molecular level to regulate gene expression has long remained enigmatic. The identification of the transcription factors YAP and TAZ as mechanotransducers started to fill this gap. YAP and TAZ read a broad range of mechanical cues, from shear stress to cell shape and extracellular matrix rigidity, and translate them into cell-specific transcriptional programmes. YAP and TAZ mechanotransduction is critical for driving stem cell behaviour and regeneration, and sheds new light on the mechanisms by which aberrant cell mechanics is instrumental for the onset of multiple diseases, such as atherosclerosis, fibrosis, pulmonary hypertension, inflammation, muscular dystrophy and cancer.
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影响因子：
8.8
作者：
Beyer, Tobias A.;Weiss, Alexander;Wrana, Jeffrey L.
通讯作者：
Wrana, Jeffrey L.
DOI：
10.1126/science.1171643
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Discher DE;Mooney DJ;Zandstra PW
通讯作者：
Zandstra PW
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
50.3
作者：
Feng X;Degese MS;Iglesias-Bartolome R;Vaque JP;Molinolo AA;Rodrigues M;Zaidi MR;Ksander BR;Merlino G;Sodhi A;Chen Q;Gutkind JS
通讯作者：
Gutkind JS
影响因子：
64.5
作者：
Azzolin, Luca;Panciera, Tito;Piccolo, Stefano
通讯作者：
Piccolo, Stefano