COPD as a systemic disease: impact on physical functional limitations.
COPD as a systemic disease: impact on physical functional limitations.
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DOI：
10.1016/j.amjmed.2008.04.030
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发表时间：
2008-09
影响因子：
5.9
通讯作者：
Iribarren, Carlos
中科院分区：
文献类型：
--
作者：
Eisner, Mark D.;Blanc, Paul D.;Yelin, Edward H.;Sidney, Stephen;Katz, Patricia P.;Ackerson, Lynn;Lathon, Phenius;Tolstykh, Irina;Omachi, Theodore;Byl, Nancy;Iribarren, Carlos
虽然慢性阻塞性肺疾病（COPD）对身体健康有重大影响，但COPD对身体功能限制的具体影响尚未明确。我们的目的是阐明身体功能的限制，直接归因于COPD相比，匹配的参照组没有条件。我们使用FLOW在COPD成人（n= 1，202）和按年龄、性别和种族匹配的参照受试者（n=302）中进行的（功能、生活、结局和工作）队列研究，使用经验证的指标研究COPD对各种功能限制风险的影响：下肢功能（短期体能成套测验，SPPB），次极量运动能力（六分钟步行测试，SMWT）、站立平衡（功能前伸测试）、骨骼肌力量（测力计手动肌肉测试）和自我报告的功能限制（标准化项目组合）。多变量分析用于控制年龄、性别、种族、身高、教育程度和吸烟的混杂因素。COPD与下肢功能较差（COPD与参考患者的平均SPPB评分降低-1.0分; 95% CI -1.25至-0.73患者）和SMWT期间步行距离较少（-334英尺; 95% CI -384至-282英尺）相关。COPD还与测试的每个肌肉群中的较弱肌肉力量相关，包括上肢和下肢（所有病例中p<0.0001），并且自我报告的功能限制风险更大（OR 6.4; 95% CI 3.7至10.9）。一系列广泛的身体功能限制可特别归因于COPD。COPD影响远离肺的多个身体系统。
Although chronic obstructive pulmonary disease (COPD) has a major impact on physical health, the specific impact of COPD on physical functional limitations has not been clearly characterized. We aimed to elucidate the physical functional limitations that are directly attributable to COPD compared to a matched referent group without the condition. We used the FLOW (Function, Living, Outcomes, and Work) cohort study of adults with COPD (n=1,202) and referent subjects matched by age, sex, and race (n=302) to study the impact of COPD on the risk of a broad array of functional limitations using validated measures: lower extremity function (Short Physical Performance Battery, SPPB), submaximal exercise performance (Six Minute Walk Test, SMWT), standing balance (Functional Reach Test), skeletal muscle strength (manual muscle testing with dynamometry), and self-reported functional limitation (standardized item battery). Multivariate analysis was used to control for confounding by age, sex, race, height, educational attainment, and cigarette smoking. COPD was associated with poorer lower extremity function (mean SPPB score decrement for COPD vs. referent -1.0 points; 95% CI -1.25 to -0.73 pts) and less distance walked during the SMWT (-334 feet; 95% CI -384 to -282 ft). COPD was also associated with weaker muscle strength in every muscle group tested, including both the upper and lower extremities (p<0.0001 in all cases) and with a greater risk of self-reported functional limitation (OR 6.4; 95% CI 3.7 to 10.9). A broad array of physical functional limitations were specifically attributable to COPD. COPD affects a multitude of body systems remote from the lung.
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影响因子：
5.9
作者：
Eisner, Mark D.;Yelin, Edward H.;Blanc, Paul D.
通讯作者：
Blanc, Paul D.
影响因子：
5.6
作者：
Eisner, Mark D.;Wang, Yue;Tager, Ira B.
通讯作者：
Tager, Ira B.
DOI：
10.1093/geronj/47.3.m93
发表时间：
1992-05-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
DUNCAN, PW;STUDENSKI, S;PRESCOTT, B
通讯作者：
PRESCOTT, B
DOI：
10.1164/ajrccm.152.6.8520771
发表时间：
1995-12-01
影响因子：
24.7
作者：
HAMILTON, AL;KILLIAN, KJ;JONES, NL
通讯作者：
JONES, NL
影响因子：
168.9
作者：
Fabbri, Leonardo M.;Rabe, Klaus F.
通讯作者：
Rabe, Klaus F.