Non-genetic determinants of mosquito competence for malaria parasites.

Non-genetic determinants of mosquito competence for malaria parasites.
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DOI:
10.1371/journal.ppat.1003365
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发表时间:
2013
期刊:
影响因子:
6.7
通讯作者:
Cohuet A
Cohuet A
中科院分区:
医学1区
文献类型:
--
作者:
Lefèvre T;Vantaux A;Dabiré KR;Mouline K;Cohuet A

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了解蚊子媒介和疟疾寄生虫如何相互作用具有根本意义,它也为疾病控制提供了新的视角。已知遗传和环境背景都会影响蚊子支持疟疾发展和传播的能力,即,向量能力虽然环境的作用早已被认识到,许多工作都集中在宿主和寄生虫的遗传效应。然而,在过去的几年里,大量的研究揭示了非遗传因素可以干扰蚊子-疟原虫相互作用的多种方式。在这里,我们回顾了目前的证据,这种环境介导的影响,包括环境温度,蚊子的饮食,微生物肠道植物群,和感染史,我们确定了以前被忽视的蚊子疟原虫相互作用的其他因素。我们还讨论了流行病学的影响,以及媒介免疫和寄生虫传播策略的进化后果。最后,我们提出了进一步研究的方向,并认为,改进知识的蚊子-疟原虫相互作用的非遗传影响,可以帮助实施传统的疟疾控制措施,并有助于设计新的战略。
Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., vector competence. Although the role of environment has long been recognized, much work has focused on host and parasite genetic effects. However, the last few years have seen a surge of studies revealing a great diversity of ways in which non-genetic factors can interfere with mosquito-Plasmodium interactions. Here, we review the current evidence for such environmentally mediated effects, including ambient temperature, mosquito diet, microbial gut flora, and infection history, and we identify additional factors previously overlooked in mosquito-Plasmodium interactions. We also discuss epidemiological implications, and the evolutionary consequences for vector immunity and parasite transmission strategies. Finally, we propose directions for further research and argue that an improved knowledge of non-genetic influences on mosquito-Plasmodium interactions could aid in implementing conventional malaria control measures and contribute to the design of novel strategies.
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