Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis.
Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis.
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DOI：
10.3390/mi11100944
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发表时间：
2020-10-19
期刊：
影响因子：
3.4
通讯作者：
Rizzo JF
中科院分区：
文献类型：
--
作者：
Shire DB;Gingerich MD;Wong PI;Skvarla M;Cogan SF;Chen J;Wang W;Rizzo JF
我们回顾了十多年来视网膜假体产品开发中遇到的独特的微制造问题和解决方案，首先是麻省理工学院和哈佛医学院的教学医院，麻省眼耳发起的波士顿视网膜植入项目，后来是由一些相同的人员创建的仿生眼技术公司。这些努力最终完成了256多个通道的视觉假体设备的制造和组装，这些设备具有柔性的多电极阵列，作为临床前测试项目的一部分，这些设备成功地植入了迷你猪动物模型的视网膜下。我们报道了柔性多层，平面和穿透高密度电极阵列的加工，视网膜下植入的手术工具，以及其他部件，如线圈支撑，促进了眼周装置组件的植入。我们首先概述了我们的视觉假体系统设计的可植入部分，并详细描述了用于创建我们的系统部件的微制造方法，这些部件是在我们密封的电子封装之外组装的。我们还注意到视网膜下植入我们的微型制造部件所面临的独特手术挑战，以及如何通过设计，材料选择和制造方法解决这些问题。
We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School’s teaching hospital, the Massachusetts Eye and Ear—and later at the startup company Bionic Eye Technologies, by some of the same personnel. These efforts culminated in the fabrication and assembly of 256+ channel visual prosthesis devices having flexible multi-electrode arrays that were successfully implanted sub-retinally in mini-pig animal models as part of our pre-clinical testing program. We report on the processing of the flexible multi-layered, planar and penetrating high-density electrode arrays, surgical tools for sub-retinal implantation, and other parts such as coil supports that facilitated the implantation of the peri-ocular device components. We begin with an overview of the implantable portion of our visual prosthesis system design, and describe in detail the micro-fabrication methods for creating the parts of our system that were assembled outside of our hermetically-sealed electronics package. We also note the unique surgical challenges that sub-retinal implantation of our micro-fabricated components presented, and how some of those issues were addressed through design, materials selection, and fabrication approaches.
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DOI：
10.1002/jbm.b.31223
发表时间：
2009-05
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Cogan SF;Ehrlich J;Plante TD;Smirnov A;Shire DB;Gingerich M;Rizzo JF
通讯作者：
Rizzo JF
DOI：
10.1109/embc.2012.6345927
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Shire DB;Ellersick W;Kelly SK;Doyle P;Priplata A;Drohan W;Mendoza O;Gingerich M;McKee B;Wyatt JL;Rizzo JF
通讯作者：
Rizzo JF
影响因子：
4
作者：
Ho, Elton;Lei, Xin;Palanker, Daniel
通讯作者：
Palanker, Daniel
影响因子：
4.6
作者：
Shire, Douglas B.;Kelly, Shawn K.;Rizzo, Joseph F.
通讯作者：
Rizzo, Joseph F.
影响因子：
--
作者：
Davidsen, Rasmus Schmidt;Hemanth, Suhith;Hansen, Ole
通讯作者：
Hansen, Ole