Transcriptional regulation of tenascin genes.
Transcriptional regulation of tenascin genes.
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DOI：
10.1080/19336918.2015.1008333
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发表时间：
2015
影响因子：
3.2
通讯作者：
Chiquet M
中科院分区：
文献类型：
--
作者：
Chiovaro F;Chiquet-Ehrismann R;Chiquet M
Tenascin家族的细胞外基质蛋白在结构域结构上彼此相似，并且在调节细胞黏附和细胞对生长因子的反应方面也具有共同的功能。尽管有这些共同的特征，但这4种脊椎动物的腱蛋白表现出非常不同的表达模式。Tenascin-R是中枢神经系统所特有的。Tenascin-C是一种受多种刺激(生长因子、细胞因子、机械应力)控制的“癌胎儿”蛋白，但在空间和时间上存在局限性。相反，Tenascin-X是结缔组织的组成成分，其水平几乎不受外界因素的影响。Tenascin-W的表达与Tenascin-C相似，但更为有限。根据其高度调控的表达，Tenascin-C和-W基因的启动子含有TATA盒，而其他2个Tenascin基因的启动子不含TATA盒。本文综述了目前已知的4个Tenascin基因在发育和疾病中的复杂转录调控。
Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors. Despite these common features, the 4 vertebrate tenascins exhibit vastly different expression patterns. Tenascin-R is specific to the central nervous system. Tenascin-C is an “oncofetal” protein controlled by many stimuli (growth factors, cytokines, mechanical stress), but with restricted occurrence in space and time. In contrast, tenascin-X is a constituitive component of connective tissues, and its level is barely affected by external factors. Finally, the expression of tenascin-W is similar to that of tenascin-C but even more limited. In accordance with their highly regulated expression, the promoters of the tenascin-C and -W genes contain TATA boxes, whereas those of the other 2 tenascins do not. This article summarizes what is currently known about the complex transcriptional regulation of the 4 tenascin genes in development and disease.
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DOI：
10.1007/s00259-013-2658-6
发表时间：
2014-05-01
影响因子：
9.1
作者：
Aloj, Luigi;D'Ambrosio, Laura;Lastoria, Secondo
通讯作者：
Lastoria, Secondo
影响因子：
--
作者：
Brellier, Florence;Martina, Enrico;Chiquet-Ehrismann, Ruth
通讯作者：
Chiquet-Ehrismann, Ruth
影响因子：
7.2
作者：
Chiquet-Ehrismann, Ruth;Tucker, Richard P.
通讯作者：
Tucker, Richard P.
DOI：
10.1139/o96-080
发表时间：
1996-01-01
期刊：
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
影响因子：
--
作者：
Chiquet, M;Matthisson, M;ChiquetEhrismann, R
通讯作者：
ChiquetEhrismann, R
影响因子：
3.8
作者：
Chevillard, Gregory;Derjuga, Anna;Blank, Volker
通讯作者：
Blank, Volker