Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort.
Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort.
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DOI：
10.1093/schbul/sbac167
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发表时间：
2023-03-15
影响因子：
6.6
通讯作者：
Rai D
中科院分区：
文献类型：
--
作者：
Dardani C;Schalbroeck R;Madley-Dowd P;Jones HJ;Strelchuk D;Hammerton G;Croft J;Sullivan SA;Zammit S;Selten JP;Rai D
关于童年自闭症特征和精神病经历之间的联系是否持续到成年，以及遗传混杂和童年创伤是否影响它们，人们知之甚少。在这里，我们调查了儿童期自闭症特征和精神病经历之间的关联，直到年轻的成年，并评估精神分裂症多基因风险和童年创伤经历的影响，使用雅芳纵向研究的父母和儿童（ALSPAC）人口为基础的出生队列。我们使用了广泛的自闭症特征（自闭症因子平均得分）和四个二分法的自闭症特征测量，包括社交沟通困难（7岁），重复行为（5岁），社交能力（3岁）和语用语言（9岁）。在18岁和24岁时使用半结构化精神病样症状访谈（PLIKSi）评估精神病经历。通过对多个年龄段的儿童和父母进行问卷调查和访谈，评估了5至11岁之间的创伤经历。广泛的自闭症特征以及社交障碍与24岁之前令人痛苦和/或频繁的精神病经历相关（自闭症因子平均评分，n = 3707：OR 1.19，95%CI 1.01-1.39;社交障碍，n = 3384：OR 1.54，95%CI 0.97-2.45）。童年创伤介导了相当大比例的已确定的关联（分别约28%和36%，最大n = 3577）。精神分裂症多基因风险似乎没有混淆的协会。多重插补分析（最大n = 13 105）得出了相当的结果。童年创伤可能是一个重要的，潜在的自闭症特征和精神病性精神病理学发病之间的可修改的途径。
Little is known on whether associations between childhood autistic traits and psychotic experiences persist into adulthood and whether genetic confounding and childhood trauma influence them. Here we investigate the associations between childhood autistic traits and psychotic experiences until young adulthood and assess the influence of schizophrenia polygenic risk and childhood traumatic experiences, using the Avon Longitudinal Study of Parents and Children (ALSPAC) population-based birth cohort. We used a measure of broad autistic traits (autism factor mean score), and four dichotomised measures of autistic traits capturing social communication difficulties (age 7), repetitive behaviours (age 5), sociability (age 3), and pragmatic language (age 9). Psychotic experiences were assessed at ages 18 and 24 using the semi-structured Psychosis-Like Symptoms interview (PLIKSi). Traumatic experiences between ages 5 and 11 were assessed with questionnaires and interviews administered to children and parents at multiple ages. Broad autistic traits, as well as social communication difficulties, were associated with psychotic experiences that were distressing and/or frequent until age 24 (autism factor mean score, n = 3707: OR 1.19, 95%CI 1.01–1.39; social communication difficulties, n = 3384: OR 1.54, 95%CI 0.97–2.45). Childhood trauma mediated a substantial proportion of the identified associations (~28% and 36% respectively, maximum n = 3577). Schizophrenia polygenic risk did not appear to confound the associations. Multiple imputation analyses (maximum n = 13 105) yielded comparable results. Childhood trauma may be an important, potentially modifiable pathway between autistic features and later onset of psychotic psychopathology.
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影响因子：
7.2
作者：
Lee KJ;Tilling KM;Cornish RP;Little RJA;Bell ML;Goetghebeur E;Hogan JW;Carpenter JR;STRATOS initiative
通讯作者：
STRATOS initiative
影响因子：
3.9
作者：
Kerns, Connor Morrow;Newschaffer, Craig J.;Berkowitz, Steven J.
通讯作者：
Berkowitz, Steven J.
DOI：
10.1016/j.jaac.2018.09.446
发表时间：
2019-06-01
影响因子：
13.3
作者：
Foss-Feig, Jennifer H.;Velthorst, Eva;Bearden, Carrie E.
通讯作者：
Bearden, Carrie E.
影响因子：
3.2
作者：
Demirkaya, Sevcan Karakoc;Tutkunkardas, Mustafa Deniz;Mukaddes, Nahit Motavalli
通讯作者：
Mukaddes, Nahit Motavalli
影响因子：
7.6
作者：
Goodman, R;Ford, T;Meltzer, H
通讯作者：
Meltzer, H