Anterior cingulate cortex activity during attentional control corresponds with rumination in depression and social anxiety.
Anterior cingulate cortex activity during attentional control corresponds with rumination in depression and social anxiety.
复制标题
前扣带回皮质在注意控制时的活动与抑郁和社交焦虑时的沉思相对应。
DOI：
10.1016/j.pscychresns.2021.111385
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发表时间：
2021-11-30
期刊：
影响因子：
--
通讯作者：
Klumpp H
中科院分区：
文献类型：
--
作者：
Sheena MK;Jimmy J;Burkhouse KL;Klumpp H
沉思和忧虑是两种跨诊断的持续性认知，具有重叠和不同的特征。虽然持续认知的机制仍然不完整，有限的数据表明，前扣带皮层（ACC），因为它涉及到自上而下的功能有助于持续认知的内化条件。目前的研究将这项工作扩展到重度抑郁症（n=39）或社交焦虑症（n=42）患者。在功能磁共振成像过程中，参与者观看的图像包括叠加在任务无关的威胁或中性面孔上的字母串。中等任务难度，有一个低的知觉负荷条件下，目标字母是在一个字符串的相同的字母和高负荷条件下，目标字母在一个混合的字母串增加任务难度。感兴趣区（ROI）包括背侧ACC和吻侧ACC。双侧杏仁核也进行了检查。结果显示，诊断组的反刍和担忧水平相似。探索性分层回归分析，包括临床指标，任务性能，和4个ROI显示显着减少背侧ACC的参与，在低（与高）负荷任务无关的面孔对应更多的反刍，但不担心，无论诊断状态。然而，ACC的发现没有生存Bonferroni校正。初步结果表明，注意控制过程中的背侧ACC反应可能是反刍的转诊断机制。
Rumination and worry are transdiagnostic perseverative cognitions that have overlapping and distinct characteristics. While the mechanisms of perseverative cognitions remain incomplete, limited data indicate anterior cingulate cortex (ACC) as it relates to top-down functions contributes to perseverative cognitions in internalizing conditions. The current study extends this work in patients with major depression (n=39) or social anxiety (n=42). During fMRI, participants viewed images comprising letter strings superimposed on task-irrelevant threatening or neutral faces. To moderate task difficulty, there was a low perceptual load condition where the target letter was in a string of identical letters and high load condition with the target letter in a mixed letter string increasing task difficulty. Regions of interest (ROI) comprised dorsal ACC and rostral ACC. Bilateral amygdala was also examined. Results showed diagnostic groups had similar levels of rumination and worry. Exploratory hierarchical regression analysis comprising clinical measures, task performance, and the 4 ROIs revealed significantly less dorsal ACC engagement during low (vs. high) load to task-irrelevant faces corresponded with more rumination, but not worry, regardless of diagnostic status. However, the ACC finding did not survive Bonferroni correction. Preliminary results suggest dorsal ACC response during attentional control may serve as a transdiagnostic mechanism of rumination.
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影响因子：
2.5
作者：
Fan, Jin;Gu, Xiaosi;Guise, Kevin G.;Liu, Xun;Fossella, John;Wang, Hongbin;Posner, Michael I.
通讯作者：
Posner, Michael I.
影响因子：
2.8
作者：
Fresco, DM;Frankel, AN;Heimberg, RG
通讯作者：
Heimberg, RG
影响因子：
4.1
作者：
Donaldson, Catherine;Lam, Dominic;Mathews, Andrew
通讯作者：
Mathews, Andrew
DOI：
10.1111/j.2044-8341.1959.tb00467.x
发表时间：
1959-01-01
期刊：
BRITISH JOURNAL OF MEDICAL PSYCHOLOGY
影响因子：
--
作者：
HAMILTON, M
通讯作者：
HAMILTON, M
影响因子：
4.1
作者：
BROWN, TA;ANTONY, MM;BARLOW, DH
通讯作者：
BARLOW, DH