MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study.
MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study.
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DOI：
10.1007/s10552-010-9633-3
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发表时间：
2010-12
影响因子：
2.3
通讯作者：
Berwick, Marianne
中科院分区：
文献类型：
--
作者：
Kricker, Anne;Armstrong, Bruce K.;Goumas, Chris;Kanetsky, Peter;Gallagher, Richard P.;Begg, Colin B.;Millikan, Robert C.;Dwyer, Terence;Rosso, Stefano;Marrett, Loraine D.;Thomas, Nancy E.;Berwick, Marianne
We investigated whether MC1R genotype modifies the effect of sun exposure on melanoma risk in 1,018 cases with multiple melanomas (MPM) and 1,875 controls with one melanoma (SPM). There was some suggestion that MC1R genotype modified the effect of beach and water activities on MPM risk: ORs were 1.94 (95% CI 1.40–2.70) for any activities for no R variants and 1.39 (95% CI 1.05–1.84) with R variants (R151C, R160W, D294H, D84E) (p for interaction 0.08). MC1R modification of sun exposure effects appeared most evident for MPM of the head and neck: for early life ambient UV the OR was 4.23 (95% CI 1.76–10.20) with no R and 1.04 (95% CI 0.40–2.68) with R (p for interaction=0.01; p for three-way interaction=0.01). Phenotype modified the effect of sun exposure and MPM in a similar manner. We conclude that MC1R and pigmentary phenotype may modify the effects of sun exposure on melanoma risk on more continuously sun-exposed skin. Possible explanations include that risk may saturate with higher sun sensitivity for melanomas on continuously sun-exposed sites but continue to increase as sun exposure increases with lower sun sensitivity, or that sun sensitive people adapt their behaviour by increasing sun protection when exposed.
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DOI：
10.1093/jnci/dji176
发表时间：
2005-07-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Landi, MT;Kanetsky, PA;Pfeiffer, RM
通讯作者：
Pfeiffer, RM
影响因子：
2.2
作者：
Galore, Gilli;Azizi, Esther;Friedman, Eitan
通讯作者：
Friedman, Eitan
影响因子：
6.5
作者：
Duffy, David L.;Zhao, Zhen Z.;Sturm, Richard A.;Hayward, Nicholas K.;Martin, Nicholas G.;Montgomery, Grant W.
通讯作者：
Montgomery, Grant W.
一项全基因组关联研究确定了与头发颜色和皮肤色素沉着相关的新等位基因。
影响因子：
4.5
作者：
Han, Jiali;Kraft, Peter;Nan, Hongmei;Guo, Qun;Chen, Constance;Qureshi, Abrar;Hankinson, Susan E.;Hu, Frank B.;Duffy, David L.;Zhao, Zhen Zhen;Martin, Nicholas G.;Montgomery, Grant W.;Hayward, Nicholas K.;Thomas, Gilles;Hoover, Robert N.;Chanock, Stephen;Hunter, David J.
通讯作者：
Hunter, David J.
影响因子：
5
作者：
Dwyer, T;Stankovich, JM;Sale, MM
通讯作者：
Sale, MM