Histone variants: dynamic punctuation in transcription.
Histone variants: dynamic punctuation in transcription.
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DOI：
10.1101/gad.238873.114
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发表时间：
2014-04-01
影响因子：
10.5
通讯作者：
Henikoff S
中科院分区：
文献类型：
--
作者：
Weber CM;Henikoff S
真核基因调控涉及到将基因组打包到核小体和允许获得调控蛋白和RNA聚合酶之间的平衡。核小体由包裹在组蛋白核心上的DNA组成，是基因调控的组成部分，限制了对调控序列和潜在模板的访问。在这篇综述中，Weber和Henikoff考虑了组蛋白变体及其相互作用的伙伴如何通过创建独特的染色质状态参与转录调控。真核基因调控涉及到将基因组打包到核小体和允许获得调控蛋白和RNA聚合酶之间的平衡。核小体是基因调控的组成部分，它限制对调控序列和潜在模板的访问。虽然规范的组蛋白包装了新复制的基因组，但它们可以被组蛋白变体取代，组蛋白变体可以改变核小体的结构、稳定性、动力学，并最终改变DNA的可及性。在这里，我们考虑组蛋白变体及其相互作用的伙伴如何通过创建独特的染色质状态参与转录调控。
Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes, consisting of DNA wrapped around a core of histone proteins, are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. In this review, Weber and Henikoff consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states. Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas canonical histones package the newly replicated genome, they can be replaced with histone variants that alter nucleosome structure, stability, dynamics, and, ultimately, DNA accessibility. Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states.
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