Repeated mirtazapine nullifies the maintenance of previously established methamphetamine-induced conditioned place preference in rats.
Repeated mirtazapine nullifies the maintenance of previously established methamphetamine-induced conditioned place preference in rats.
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DOI：
10.1016/j.bbr.2011.07.009
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发表时间：
2011-11-20
影响因子：
2.7
通讯作者：
Napier, T. Celeste
中科院分区：
文献类型：
--
作者：
Voigt, Robin M.;Mickiewicz, Amanda L.;Napier, T. Celeste
非典型抗抑郁药米氮平可增强单胺能传递;因此，米氮平治疗可对抗与甲基苯丙胺滥用戒断相关的单胺系统低活化。人类成瘾治疗可能需要在大脑和行为适应不良建立后进行长期给药。为了在大鼠中模拟这种情况，我们确定急性或重复米氮平治疗是否可以拮抗先前确定的重复甲基苯丙胺的后果。使用甲基苯丙胺诱导的条件性位置偏爱（CPP），其中甲基苯丙胺（1 mg/kg，i. p.）在独特的环境中每天一次给药，持续三天，其间在交替的环境中注射盐水。随后，米氮平（5 mg/kg，i. p.）在饲养笼中以10次每日一次注射或单次注射给药。在末次米氮平注射后3天，在无药物大鼠中测定CPP的表达。甲基苯丙胺诱导的CPP的表达被抑制10米氮平的家庭笼管理，但不是由一个单一的注射米氮平。这些结果表明，米氮平可以抑制甲基苯丙胺诱导的CPP的维持，并且治疗持续时间和/或治疗时机有助于米氮平的这种作用。
The atypical antidepressant mirtazapine enhances monoaminergic transmission; thus, mirtazapine therapy may counter the hypo-activation of monoamine systems associated with withdrawal from methamphetamine abuse. Human addiction therapy will likely require chronic administration that is given after brain and behavioral maladaptations are established. To emulate this scenario in rats, we ascertained if acute or repeated mirtazapine treatments could antagonize previously established consequences of repeated methamphetamine. Methamphetamine-induced conditioned place preference (CPP) was used, wherein methamphetamine (1mg/kg, i.p.) was administered in a unique environmental context once-daily for three days interposed by saline injections in an alternate context. Subsequently, mirtazapine (5mg/kg, i.p.) was administered in the home cage either as 10 once-daily injections or a single injection. The expression of CPP was determined in drug-free rats three days after the last mirtazapine injection. Expression of methamphetamine-induced CPP was inhibited by 10 home cage administrations of mirtazapine but not by a single injection of mirtazapine. These findings reveal that mirtazapine can inhibit the maintenance of methamphetamine-induced CPP and that treatment duration and/or treatment timing contributes to this effect of mirtazapine.
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影响因子：
2.9
作者：
Egashira, N;Yano, A;Fujiwara, M
通讯作者：
Fujiwara, M
影响因子：
2.7
作者：
Feltenstein, Matthew W.;See, Ronald E.
通讯作者：
See, Ronald E.
影响因子：
3.8
作者：
Cruickshank, Christopher C.;Montebello, Mark E.;Shand, Diana
通讯作者：
Shand, Diana
影响因子：
6.6
作者：
Haddjeri, N;Blier, P;de Montigny, C
通讯作者：
de Montigny, C
DOI：
10.1111/j.1749-6632.1996.tb17437.x
发表时间：
1996-01-01
期刊：
CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE
影响因子：
--
作者：
Amano, T;Matsubayashi, H;Sasa, M
通讯作者：
Sasa, M