Novel molecular pathways in Gorham disease: implications for treatment.
Novel molecular pathways in Gorham disease: implications for treatment.
复制标题
戈勒姆病的新分子途径：对治疗的影响。
DOI：
10.1002/pbc.24832
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发表时间：
2014-03
影响因子：
3.2
通讯作者：
Ebb, David H.
中科院分区：
文献类型：
--
作者：
Hagendoorn, Jeroen;Yock, Torunn I.;Borel, Inne H. M.;Padera, Timothy P.;Ebb, David H.
Rapid advances in evidence-based treatment schedules are a hallmark of modern oncology. In rare neoplastic diseases, however, clinical expertise is hard to build and evidence based on randomized trials almost impossible to conduct. Gorham disease is a rare form of lymphatic proliferation accompanied by osteolysis, which usually occurs in young adults. Despite the fact that the clinical course of Gorham disease is often devastating and occasionally fatal, insights into its biological background are sparse and standardized treatment unavailable. Interestingly, recent knowledge on the mechanisms of lymphangiogenesis may help elucidate the pathophysiology of Gorham disease and lead to novel treatment targets. Here, we discuss our current understanding of Gorham disease, discuss established and emerging therapeutic strategies, and attempt to frame a treatment rationale.
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影响因子：
1.7
作者：
HEJGAARD, N;OLSEN, PR
通讯作者：
OLSEN, PR
影响因子：
78.5
作者：
Bartlett, JB;Dredge, K;Dalgleish, AG
通讯作者：
Dalgleish, AG
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
DOI：
10.2106/00004623-195537050-00008
发表时间：
1955-01-01
影响因子：
5.3
作者：
GORHAM, LW;STOUT, AP
通讯作者：
STOUT, AP
影响因子：
3.3
作者：
Edwards, James R.;Williams, Kelly;Athanasou, Nicholas A.
通讯作者：
Athanasou, Nicholas A.