Acute and chronic regulation of aldosterone production.
Acute and chronic regulation of aldosterone production.
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DOI：
10.1016/j.mce.2011.07.034
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发表时间：
2012-03-24
影响因子：
4.1
通讯作者：
Rainey, William E.
中科院分区：
文献类型：
--
作者：
Hattangady, Namita G.;Olala, Lawrence O.;Bollag, Wendy B.;Rainey, William E.
醛固酮是肾上腺合成的主要盐皮质激素。醛固酮的分泌受到肾上腺皮质小球细胞的严格调节，这是由于CYP11B2在最外层区域（小球细胞）的选择性表达。醛固酮主要负责通过在某些特定激动剂的调节下吸收电解质和水来调节全身血压。血管紧张素II（AngII）、钾离子（K+）和促肾上腺皮质激素（ACTH）是调节醛固酮分泌的主要生理激动剂。参与该过程的机制可以在刺激后几分钟（急性）通过增加类固醇生成急性调节（星星）蛋白的表达和磷酸化来调节，在数小时至数天（慢性）通过增加参与醛固酮合成的酶，特别是醛固酮合酶（CYP 11 B2）的表达来调节。这些过程中的任何一个不平衡都可能导致几种醛固酮过量疾病。在这篇综述中，我们试图总结关键的分子事件参与，并特别归因于急性和慢性阶段的醛固酮分泌。
Aldosterone is the major mineralocorticoid synthesized by the adrenal. Secretion of aldosterone is regulated tightly by the adrenocortical glomerulosa cells due to the selective expression of CYP11B2 in the outermost zone, the zona glomerulosa. Aldosterone is largely responsible for regulation of systemic blood pressure through the absorption of electrolytes and water under the regulation of certain specific agonists. Angiotensin II (Ang II), potassium (K+) and adrenocorticotropin (ACTH) are the main physiological agonists which regulate aldosterone secretion. The mechanisms involved in this process may be regulated minutes after a stimulus (acutely) through increased expression and phosphorylation of the steroidogenic acute regulatory (StAR) protein, over hours to days (chronically) by increased expression of the enzymes involved in the synthesis of aldosterone, particularly aldosterone synthase (CYP11B2). Imbalance in any of these processes may lead to several aldosterone excess disorders. In this review we attempt to summarize the key molecular events involved in and specifically attributed to the acute and chronic phases of aldosterone secretion.
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影响因子：
3.5
作者：
Bassett, MH;Zhang, Y;Rainey, WE
通讯作者：
Rainey, WE
影响因子：
--
作者：
Bassett, MH;Suzuki, T;Rainey, WE
通讯作者：
Rainey, WE
影响因子：
2.1
作者：
Breault, L;Lehoux, JG;GalloPayet, N
通讯作者：
GalloPayet, N
影响因子：
8.3
作者：
BERK, BC;VEKSHTEIN, V;TSUDA, T
通讯作者：
TSUDA, T
影响因子：
4.1
作者：
Bollag, Wendy B.;Kent, Patricia;Calle, Roberto A.
通讯作者：
Calle, Roberto A.