Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity
Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity
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MAIT细胞的激活在病毒载体疫苗免疫原性中起着关键作用
DOI：
10.1101/661397
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Provine N
中科院分区：
文献类型：
--
作者：
Provine N
Mucosal-associated invariant T (MAIT) cells can be activated by viruses through a cytokine-dependent mechanism, and thereby protect from lethal infection. Given this, we reasoned MAIT cells may have a critical role in the immunogenicity of replication-incompetent adenovirus vectors, which are novel and highly potent vaccine platforms.In vitro, ChAdOx1 (Chimpanzee Adenovirus Ox1) induced potent activation of MAIT cells. Activation required transduction of monocytes and plasmacytoid dendritic cells to produce IL-18 and IFN-α, respectively. IFN-α-induced monocyte-derived TNF-α was identified as a novel intermediate in this activation pathway, and activation required combinatorial signaling of all three cytokines. Furthermore, ChAdOx1-inducedin vivoMAIT cell activation in both mice and human volunteers. Strikingly, MAIT cell activation was necessaryin vivofor development of ChAdOx1-induced HCV-specific CD8 T cell responses. These findings define a novel role for MAIT cells in the immunogenicity of viral vector vaccines, with potential implications for future design.One sentence summaryRobust immunogenicity of candidate adenovirus vaccine vectors requires the activation of unconventional T cells.
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影响因子：
7.3
作者：
Provine NM;Binder B;FitzPatrick MEB;Schuch A;Garner LC;Williamson KD;van Wilgenburg B;Thimme R;Klenerman P;Hofmann M
通讯作者：
Hofmann M
DOI：
10.4049/jimmunol.1600591
发表时间：
2016-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Provine NM;Larocca RA;Aid M;Penaloza-MacMaster P;Badamchi-Zadeh A;Borducchi EN;Yates KB;Abbink P;Kirilova M;Ng'ang'a D;Bramson J;Haining WN;Barouch DH
通讯作者：
Barouch DH
影响因子：
3.5
作者：
MURATA, M;MIYASHITA, S;KATUNUMA, N
通讯作者：
KATUNUMA, N
影响因子：
82.9
作者：
Coll, Rebecca C.;Robertson, Avril A. B.;Chae, Jae Jin;Higgins, Sarah C.;Munoz-Planillo, Raul;Inserra, Marco C.;Vetter, Irina;Dungan, Lara S.;Monks, Brian G.;Stutz, Andrea;Croker, Daniel E.;Butler, Mark S.;Haneklaus, Moritz;Sutton, Caroline E.;Nunez, Gabriel;Latz, Eicke;Kastner, Daniel L.;Mills, Kingston H. G.;Masters, Seth L.;Schroder, Kate;Cooper, Matthew A.;O'Neill, Luke A. J.
通讯作者：
O'Neill, Luke A. J.
影响因子：
3.7
作者：
Dicks MD;Spencer AJ;Edwards NJ;Wadell G;Bojang K;Gilbert SC;Hill AV;Cottingham MG
通讯作者：
Cottingham MG