Sialic acids in human health and disease.

Sialic acids in human health and disease.
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DOI:
10.1016/j.molmed.2008.06.002
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发表时间:
2008-08
影响因子:
13.6
通讯作者:
Varki A
Varki A
中科院分区:
医学1区
文献类型:
--
作者:
Varki A

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所有脊椎动物细胞的表面都装饰着密集而复杂的糖链排列,这些糖链大多附着在蛋白质和脂质上。大多数可溶性分泌蛋白也同样用这种聚糖修饰。唾液酸是一个不同的糖单位家族,具有9个碳的主链,通常连接在这些链的最外层。鉴于其位置和普遍分布,唾液酸可以介导或调节多种生理和病理过程。这篇综述考虑了它们在人体生理学和疾病方面的一些已建立的和新出现的作用的例子。
The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typically found attached to the outermost ends of these chains. Given their location and ubiquitous distribution, sialic acids can mediate or modulate a wide variety of physiological and pathological processes. This review considers some examples of their established and newly emerging roles in aspects of human physiology and disease.
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