Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma.
Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma.
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DOI：
10.1186/1746-1596-9-47
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发表时间：
2014-03-04
影响因子：
2.6
通讯作者：
Qin CK
中科院分区：
文献类型：
--
作者：
Su ZX;Zhao J;Rong ZH;Geng WM;Wu YG;Qin CK
越来越多的证据表明microRNA-25（miR-25）的上调与几种类型的人类恶性实体瘤的预后相关。然而，miR-25的表达是否对肝细胞癌（HCC）的预后有影响尚不清楚。通过定量逆转录聚合酶链反应（qRT-PCR）一式三份验证miR-25的差异表达量。生存率采用对数秩检验，生存曲线采用Kaplan-Meier法。多因素分析采用考克斯回归模型。与癌旁正常组织相比，HCC组织中miR-25的表达显著上调（p<0.0001）。miR-25高表达患者的总生存期短于miR-25低表达患者（中位总生存期，31.0个月vs 42.9个月，p=0.0192）。多变量考克斯回归分析显示miR-25表达（HR=2.179; p=0.001）、TNM分期（HR=1.782; p=0.014）和静脉侵犯（HR=1.624; p=0.020）是影响总生存期的独立预后因素。我们的数据表明，miR-25在HCC组织中的过表达对预后不良具有预测价值。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1989618421114309
Accumulating evidence has shown that up-regulation of microRNA-25(miR-25) is associated with the prognosis of several types of human malignant solid tumors. However, whether miR-25 expression has influence on the prognosis of hepatocellular carcinoma (HCC) is still unknown. The differentially expressed amount of the miR-25 was validated in triplicate by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Survival rate was analyzed by log-rank test, and survival curves were plotted according to Kaplan–Meier. Multivariate analysis of the prognostic factors was performed with Cox regression model. The expression of miR-25 was significantly upregulated in HCC tissues when compared with adjacent normal tissues (p<0.0001). Patients who had high miR-25 expression had a shorter overall survival than patients who had low miR-25 expression (median overall survival, 31.0 months versus 42.9 months, p=0.0192). The multivariate Cox regression analysis indicated that miR-25 expression (HR=2.179; p=0.001), TNM stage (HR=1.782; p=0.014), and vein invasion (HR=1.624; p=0.020) were independent prognostic factors for overall survival. Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1989618421114309
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